A1WR06 (A1WR06_VEREI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108 RuleBase RU003490
EC=2.7.7.60 HAMAP MF_00108 RuleBase RU003490

Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108

Gene names

Name:	ispD HAMAP MF_00108
Ordered Locus Names:	Veis_4360

Organism

Verminephrobacter eiseniae (strain EF01-2) [Complete proteome] [HAMAP]

Taxonomic identifier

391735 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Verminephrobacter

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 RuleBase RU003490 SAAS SAAS018294
Catalytic activity	CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 RuleBase RU003490 SAAS SAAS018294
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004138
Sequence similarities	Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393
Molecular function	Nucleotidyltransferase HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393 EMBL ABM60063.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Site	4	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	30	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	165	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
	Site	218	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

	Sequence		Length	Mass (Da)
	A1WR06 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 239A3B7BE1078AFE	FASTA	247	25,355
	10 20 30 40 50 60 MGTRAAAAGG AASSCPVSAP CPALAPALPK QYQLLAGRPM VLHTLAAFAG VGRLLGTLVA 70 80 90 100 110 120 VAPGDHFLAQ HAQPAFFVVP CGGPRRADTV LGGLRALLAR GAQPDDWVLV HDAARCLVTS 130 140 150 160 170 180 GQIEALMEQC ANDSVGGLLA LRLTDTLKAA SDGPGGLRVA GTLERSDKWL AQTPQMFRIG 190 200 210 220 230 240 PLLAAIEQAG GDITDEASAM EAQGLRPRLV PGGAQNFKVT YPDDFALAAA VLAQRVPGGQ RAESLVR

References

[1]

"Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EF01-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000542 Genomic DNA. Translation: ABM60063.1.
RefSeq	YP_999081.1. NC_008786.1.
3D structure databases
ProteinModelPortal	A1WR06.
ModBase	Search...
Protein-protein interaction databases
STRING	A1WR06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4695050.
GenomeReviews	Gene locus Veis_4360 in contig CP000542_GR.
KEGG	vei:Veis_4360.
PATRIC	24022615. VBIVerEis120356_4683.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1211.
HOGENOM	HBG672839.
OMA	FPQGAIL.
PhylomeDB	A1WR06.
Enzyme and pathway databases
BioCyc	VEIS391735:VEIS_4360-MONOMER.
Family and domain databases
HAMAP	MF_00108. IspD. [Tree]
InterPro	IPR001228. ISPD_synthase. IPR018294. ISPD_synthase_CS. [Graphical view]
KO	K00991.
Pfam	PF01128. IspD. 1 hit. [Graphical view]
PROSITE	PS01295. ISPD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1WR06_VEREI

Accession

Primary (citable) accession number: A1WR06

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)