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A1WNW9

- A1WNW9_VEREI

UniProt

A1WNW9 - A1WNW9_VEREI

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Protein

Phosphoribosylformylglycinamidine synthase

Gene
purL, Veis_3609
Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate By similarity.UniRule annotation

Catalytic activityi

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei684 – 6841ATP; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi685 – 6851Magnesium By similarityUniRule annotation
Metal bindingi724 – 7241Magnesium By similarityUniRule annotation
Metal bindingi728 – 7281Magnesium By similarityUniRule annotation
Metal bindingi895 – 8951Magnesium By similarityUniRule annotation
Binding sitei897 – 8971ATP By similarityUniRule annotation
Active sitei1177 – 11771Nucleophile By similarityUniRule annotation
Active sitei1298 – 12981 By similarityUniRule annotation
Active sitei1300 – 13001 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 32812ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. phosphoribosylformylglycinamidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-3653-MONOMER.
UniPathwayiUPA00074; UER00128.

Protein family/group databases

MEROPSiC56.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthaseUniRule annotation (EC:6.3.5.3UniRule annotation)
Short name:
FGAM synthaseUniRule annotation
Short name:
FGAMSUniRule annotation
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Gene namesi
Name:purLUniRule annotation
Ordered Locus Names:Veis_3609Imported
OrganismiVerminephrobacter eiseniae (strain EF01-2)Imported
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391735.Veis_3609.

Structurei

3D structure databases

ProteinModelPortaliA1WNW9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1084 – 1316233Glutamine amidotransferase type-1 By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains glutamine amidotransferase type-1 domain.SAAS annotations
Contains glutamine amidotransferase type-domain.SAAS annotations
In the N-terminal section; belongs to the FGAMS family.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0046.
HOGENOMiHOG000261359.
KOiK01952.
OMAiMSPREIW.
OrthoDBiEOG6FNHHR.

Family and domain databases

Gene3Di3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 3 hits.
TIGRFAMsiTIGR01735. FGAM_synt. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WNW9-1 [UniParc]FASTAAdd to Basket

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MTTLAGGNAL SPFRARQLQS ALADIHPGIT GIAARFVHLV LTDTAPAPAQ     50
QQRLAALLRY GDPYAGPVDG CAIIVTPRLG TLSPWASKAT DIARNCGLAV 100
RHLERSTEYR IRLRAGRLTD AERDRIAALL HDRMTESVLF DPAGLAALFT 150
ALPPARMEHV DVLGAGLAAL AAANTRLGLA LADQEMEYLV SAFTGLARNP 200
TEVELMMFAQ ANSEHCRHKI FNARFAIDGV AQEPSLFDMI RHTHQRAPGH 250
TLVAYSDNAA VMQGHLVEQF AAKMTDGADP SCAHTYAYSY QKSSSTEHLL 300
MKVETHNHPT AISPWPGAAT GAGGEIRDEG ATGRGARPRA GLTGFSVSRL 350
WGSQIGRPGH IASALQIMLE GPLGAAAFNN EFGRPNLAGY FREYEQRVGC 400
GADAVVRGYH KPIMLAGGLG VIDAALVRKI AFPAGTLLVQ LGGPGMRIGM 450
GGGAASSMAT GSNAAGLDFD SVQRGNPEIQ RRAQEVINHC AAQGAANPIL 500
AIHDVGAGGL SNALPELIHD AGRGARLDLR AVPLEDSGMS AMEIWSNESQ 550
ERYVLAIAPE SLAQLRSFCE RERCPLAVLG SATEERQLVL HDSAATAADQ 600
QLPVNLPMGV LLGQPPRMQR NASSLRRRFV PLDLSGLPLH KAVTDVLAHP 650
TVASKRFLVS IGDRTVGGLV HRDQMVGPWQ VPVADCAITL ADYQGFAGAA 700
MAIGERTPLA ALDAPASGRM AVAEAITNLL AAPIELARVK LSANWMAACG 750
EPGEDAALYA TVEAVGLELC PALGLAIPVG KDSLSMRTQW REGAGQTTVS 800
SPVSLIVSAF AALTDVRGSL TPQLDATEAE TTLVLIDLGR GRNRMGASIL 850
GQTLEQSGCP EKDGVPDLDA PQDLLALVDA VNALRAQGRL LAYHDRSDGG 900
LLATVAEMAF AGQVGVALNV DLLVTEGDGI GDSRMDTGDA KNWAGQVHAR 950
REERTLEALF SEELGVVLQV RTAERNEVMQ TLRAHGLARW SHFIGSTRPA 1000
GPRVLQVWRD AQPVFSAPLA DLQRAWDTVS WKICRQRDNP DSADAEHAAA 1050
GDPTDPGLHL HLQPTFDAPE PPAAPGLRLA RPRVAILREQ GVNSHVEMAY 1100
AFTEAGFAAC DVHMTDLQTG RVRLADFKGL VACGGFSYGD TLGAGIGWAR 1150
SISFNPALAA QFQGFFARGD TFGLGVCNGC QMFAELADII PGAQYWPRFT 1200
TNQSQRFESR LSLVQVTESP SLFLQGMAGS RLPVPVAHGE GYADFRQRGD 1250
AAQAIAALRF VDNHGAVTER YPFNPNGSPG GLTGVTTADG RFTALMPHPE 1300
RVFRNIQMSW TPGERSALSP WMRLWRNARR WVG 1333
Length:1,333
Mass (Da):142,090
Last modified:February 6, 2007 - v1
Checksum:iB763C28198478E9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM59326.1.
RefSeqiYP_998344.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM59326; ABM59326; Veis_3609.
GeneIDi4692772.
KEGGivei:Veis_3609.
PATRICi24021031. VBIVerEis120356_3893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM59326.1 .
RefSeqi YP_998344.1. NC_008786.1.

3D structure databases

ProteinModelPortali A1WNW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_3609.

Protein family/group databases

MEROPSi C56.972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM59326 ; ABM59326 ; Veis_3609 .
GeneIDi 4692772.
KEGGi vei:Veis_3609.
PATRICi 24021031. VBIVerEis120356_3893.

Phylogenomic databases

eggNOGi COG0046.
HOGENOMi HOG000261359.
KOi K01952.
OMAi MSPREIW.
OrthoDBi EOG6FNHHR.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00128 .
BioCyci VEIS391735:GHY5-3653-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
3.90.650.10. 1 hit.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 3 hits.
TIGRFAMsi TIGR01735. FGAM_synt. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiA1WNW9_VEREI
AccessioniPrimary (citable) accession number: A1WNW9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In Gram-negative bacteria and most eukaryotes, FGAM synthase is only formed by PurL, a single polypeptide of 140 kDa (large PurL). However in Gram-positive bacteria and archaebacteria, phosphoribosylformylglycinamidine synthase is composed of three separate proteins: PurL (small PurL), PurQ and PurS By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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