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Protein

Ribonuclease 3

Gene

rnc

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40MagnesiumUniRule annotation1
Active sitei44UniRule annotation1
Metal bindingi133MagnesiumUniRule annotation1
Active sitei136UniRule annotation1
Metal bindingi136MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:Veis_3238
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
Proteomesi
  • UP000000374 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000758471 – 247Ribonuclease 3Add BLAST247

Proteomic databases

PRIDEiA1WMW1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391735.Veis_3238

Structurei

3D structure databases

ProteinModelPortaliA1WMW1
SMRiA1WMW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 147RNase IIIUniRule annotationAdd BLAST143
Domaini174 – 244DRBMUniRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1WMW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDLIALQE RLQHVFSDPG LLERATTHRS FSAEHNERLE FLGDSVLNLA
60 70 80 90 100
VSSLLYQRLS ALPEGELSRV RANLVRQESL YQLALRLPLA QALRLGESLS
110 120 130 140 150
GNRQRRSRRR CADELQPDEA GSGGLQHPSI LADALEALIG AVYLDAGYAS
160 170 180 190 200
AQALVQRLFQ DVEISPRMQA AARDAKTALQ EWLASRKMKP PQYQVVARVG
210 220 230 240
AAHCPTFEVA CGIPALGLTE RGSAGSRQAG EQAAAAAMLA TLKARNL
Length:247
Mass (Da):26,871
Last modified:February 6, 2007 - v1
Checksum:i1BAB696E9AB98D5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000542 Genomic DNA Translation: ABM58968.1
RefSeqiWP_011810960.1, NC_008786.1

Genome annotation databases

EnsemblBacteriaiABM58968; ABM58968; Veis_3238
KEGGivei:Veis_3238

Entry informationi

Entry nameiRNC_VEREI
AccessioniPrimary (citable) accession number: A1WMW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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