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A1WMA0

- GSA_VEREI

UniProt

A1WMA0 - GSA_VEREI

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVEIS391735:GHY5-3056-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Veis_3024
    OrganismiVerminephrobacter eiseniae (strain EF01-2)
    Taxonomic identifieri391735 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
    ProteomesiUP000000374: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000300957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi391735.Veis_3024.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WMA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiFFERAST.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1WMA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPNTDLNIP LFERAKALIP GGVNSPVRAF KAVGGTPRFV KRARGAYFWD    50
    ANDQRFIDYI GSWGPMILGH GHPAVLEAVQ QAALEGLSFG APTERELELA 100
    EAILRLLPSM QMIRLVSSGT EAGMSAIRLA RGATGRSKLI KFEGCYHGHA 150
    DALLVKAGSG LATFGNATSA GVPAEVVQHT LVLEYNSIEQ LERAFALHGK 200
    ELACLIIEPI AGNMNLVRAS VPFMRRCREL CSEYGALLVL DEVMTGFRVA 250
    PGGAQSLYAR DIPGFQPDLT VLGKVIGGGM PLAAFGGSRA LMEHLAPLGA 300
    VYQAGTLSGN PVATACGLAT LRAIGQPGFF AALSARTRAL VEGLRGAAAA 350
    EGVAFSADSE GGMFGFFLLP ALPRNYAQVL QTDSARFNQL FHGLLERGIY 400
    IAPALYEAGF VSAAHSDEDI AATVAAAREV FKTLAKP 437
    Length:437
    Mass (Da):46,110
    Last modified:February 6, 2007 - v1
    Checksum:iFA3D2C2FFABA6754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM58757.1.
    RefSeqiYP_997775.1. NC_008786.1.

    Genome annotation databases

    EnsemblBacteriaiABM58757; ABM58757; Veis_3024.
    GeneIDi4694901.
    KEGGivei:Veis_3024.
    PATRICi24019803. VBIVerEis120356_3288.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM58757.1 .
    RefSeqi YP_997775.1. NC_008786.1.

    3D structure databases

    ProteinModelPortali A1WMA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391735.Veis_3024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM58757 ; ABM58757 ; Veis_3024 .
    GeneIDi 4694901.
    KEGGi vei:Veis_3024.
    PATRICi 24019803. VBIVerEis120356_3288.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi FFERAST.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci VEIS391735:GHY5-3056-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EF01-2.

    Entry informationi

    Entry nameiGSA_VEREI
    AccessioniPrimary (citable) accession number: A1WMA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3