A1WMA0 (GSA_VEREI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Veis_3024

Organism

Verminephrobacter eiseniae (strain EF01-2) [Complete proteome] [HAMAP]

Taxonomic identifier

391735 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Verminephrobacter › Verminephrobacter eiseniae

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000300957
Amino acid modifications
	Modified residue	274	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1WMA0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: FA3D2C2FFABA6754	FASTA	437	46,110
	10 20 30 40 50 60 MTPNTDLNIP LFERAKALIP GGVNSPVRAF KAVGGTPRFV KRARGAYFWD ANDQRFIDYI 70 80 90 100 110 120 GSWGPMILGH GHPAVLEAVQ QAALEGLSFG APTERELELA EAILRLLPSM QMIRLVSSGT 130 140 150 160 170 180 EAGMSAIRLA RGATGRSKLI KFEGCYHGHA DALLVKAGSG LATFGNATSA GVPAEVVQHT 190 200 210 220 230 240 LVLEYNSIEQ LERAFALHGK ELACLIIEPI AGNMNLVRAS VPFMRRCREL CSEYGALLVL 250 260 270 280 290 300 DEVMTGFRVA PGGAQSLYAR DIPGFQPDLT VLGKVIGGGM PLAAFGGSRA LMEHLAPLGA 310 320 330 340 350 360 VYQAGTLSGN PVATACGLAT LRAIGQPGFF AALSARTRAL VEGLRGAAAA EGVAFSADSE 370 380 390 400 410 420 GGMFGFFLLP ALPRNYAQVL QTDSARFNQL FHGLLERGIY IAPALYEAGF VSAAHSDEDI 430 AATVAAAREV FKTLAKP

References

[1]

"Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EF01-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000542 Genomic DNA. Translation: ABM58757.1.
RefSeq	YP_997775.1. NC_008786.1.
3D structure databases
ProteinModelPortal	A1WMA0.
ModBase	Search...
Protein-protein interaction databases
STRING	391735.Veis_3024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM58757; ABM58757; Veis_3024.
GeneID	4694901.
KEGG	vei:Veis_3024.
PATRIC	24019803. VBIVerEis120356_3288.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	FNGNPIS.
ProtClustDB	PRK00062.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_VEREI

Accession

Primary (citable) accession number: A1WMA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program