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A1WLL3

- ACDH_VEREI

UniProt

A1WLL3 - ACDH_VEREI

Protein

Acetaldehyde dehydrogenase

Gene

Veis_2782

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
    Binding sitei272 – 2721NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 1699NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciVEIS391735:GHY5-2812-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Veis_2782
    OrganismiVerminephrobacter eiseniae (strain EF01-2)
    Taxonomic identifieri391735 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
    ProteomesiUP000000374: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Acetaldehyde dehydrogenasePRO_0000387750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391735.Veis_2782.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WLL3.
    SMRiA1WLL3. Positions 2-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiREVQKYV.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1WLL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIKCALIG PGNIGTDLLA KLQRSPVLEP VWMVGIDPAS DGLKRASEMG    50
    IKTTAEGVDG LIPHMKADGV QIVFDATSAY VHAENSAKVN AQGAMMIDLT 100
    PAAIGPYCVP PVNLKQHVGR REMNVNMVTC GGQATIPMVY AVSRVQPVAY 150
    GEIVATVSSR SVGPGTRKNI DEFTRTTAGA VEKVGGARQG KAIIIINPAE 200
    PPLIMRDTVH CLVEGKPDEA AITQSIHDMI REVQKYVPGY KLVNGPVFDG 250
    QRVSVFMEVE GLGDYLPKYA GNLDIMTAAA ARTAEMFAEE ILKGELVLEP 300
    VAA 303
    Length:303
    Mass (Da):32,263
    Last modified:February 6, 2007 - v1
    Checksum:iBC5FACC2F10AC3A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM58520.1.
    RefSeqiYP_997538.1. NC_008786.1.

    Genome annotation databases

    EnsemblBacteriaiABM58520; ABM58520; Veis_2782.
    GeneIDi4695151.
    KEGGivei:Veis_2782.
    PATRICi24019299. VBIVerEis120356_3036.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM58520.1 .
    RefSeqi YP_997538.1. NC_008786.1.

    3D structure databases

    ProteinModelPortali A1WLL3.
    SMRi A1WLL3. Positions 2-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391735.Veis_2782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM58520 ; ABM58520 ; Veis_2782 .
    GeneIDi 4695151.
    KEGGi vei:Veis_2782.
    PATRICi 24019299. VBIVerEis120356_3036.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi REVQKYV.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci VEIS391735:GHY5-2812-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EF01-2.

    Entry informationi

    Entry nameiACDH_VEREI
    AccessioniPrimary (citable) accession number: A1WLL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3