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A1WK80

- UPPP_VEREI

UniProt

A1WK80 - UPPP_VEREI

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Veis_2289
Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-2315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Veis_2289
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 3919Helical; Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Undecaprenyl-diphosphataseUniRule annotationPRO_0000290779Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391735.Veis_2289.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1WK80-1 [UniParc]FASTAAdd to Basket

« Hide

MDVVLLVKAA IMGVVEGLTE FLPISSTGHL ILAGALLGFD DAKAQVFDVA    50
IQTGAILAVI LVYWAKIRAT LHALPSERQA QRLAFNLAIG FFPAVLLGLL 100
FGKAIKAHLF TPVVVASTFI IGGLVILWAE RRAPAATRIH TLDAMTAPDA 150
LKVGLVQCLA MVPGTSRSGA TIIGGMLLGL SRQAATDFSF FLAIPTLIGA 200
GVYSLYQERA LLTVADLPMF LTGLVFSFLS AWLCVRWLLR YIASHSFVPF 250
AYYRIGFGLM VLVTASTGWV PWVD 274
Length:274
Mass (Da):29,409
Last modified:February 6, 2007 - v1
Checksum:i502739B739C1491D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM58037.1.
RefSeqiWP_011810040.1. NC_008786.1.
YP_997055.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM58037; ABM58037; Veis_2289.
GeneIDi4695282.
KEGGivei:Veis_2289.
PATRICi24018273. VBIVerEis120356_2525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM58037.1 .
RefSeqi WP_011810040.1. NC_008786.1.
YP_997055.1. NC_008786.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_2289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM58037 ; ABM58037 ; Veis_2289 .
GeneIDi 4695282.
KEGGi vei:Veis_2289.
PATRICi 24018273. VBIVerEis120356_2525.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci VEIS391735:GHY5-2315-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiUPPP_VEREI
AccessioniPrimary (citable) accession number: A1WK80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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