A1WJY8 (AROE_VEREI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Veis_2197

Organism

Verminephrobacter eiseniae (strain EF01-2) [Complete proteome] [HAMAP]

Taxonomic identifier

391735 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Verminephrobacter

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325182
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A1WJY8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A3437BD165B30148	FASTA	288	29,941
	10 20 30 40 50 60 MRQTADLYCV LGNPIAHSRS PAIHARFAEL TGERIRYERR LLPIDGFARG LRDFAAQGGR 70 80 90 100 110 120 GCSVTVPFKT EALRCATACS ERAQLAGAAN TLSLHADGSI SADNTDGLGL VADITRNAGI 130 140 150 160 170 180 ALAGCDVLLV GAGGAAAGVL GPLLHAGVRH ITVANRTLAK AQALVQSHSA LAALRKTQLK 190 200 210 220 230 240 ACGLQAPLAD FDIIINASAS SLAGADVPVP ASVLRPASLA YDMMYGPAAQ GFLDWARRHG 250 260 270 280 ARPRDGLGML VEQAAEAFWL WRGLRPPSAQ VLAELQEAAA KPASGADR

References

[1]

"Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EF01-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000542 Genomic DNA. Translation: ABM57945.1.
RefSeq	YP_996963.1. NC_008786.1.
3D structure databases
ProteinModelPortal	A1WJY8.
ModBase	Search...
Protein-protein interaction databases
STRING	A1WJY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4691270.
GenomeReviews	Gene locus Veis_2197 in contig CP000542_GR.
KEGG	vei:Veis_2197.
NMPDR	fig|391735.5.peg.2075.
PATRIC	24018077. VBIVerEis120356_2432.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	A1WJY8.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	VEIS391735:VEIS_2197-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_VEREI

Accession

Primary (citable) accession number: A1WJY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program