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A1WIJ3 (GUAC_VEREI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase

EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Veis_1695
OrganismVerminephrobacter eiseniae (strain EF01-2) [Complete proteome] [HAMAP]
Taxonomic identifier391735 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP-Rule MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP-Rule MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentGMP reductase complex

Inferred from electronic annotation. Source: UniProtKB-EC

   Molecular_functionGMP reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322GMP reductase HAMAP-Rule MF_01511
PRO_0000294290

Regions

Nucleotide binding202 – 22524NADP Potential

Sites

Active site1731Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1WIJ3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C41A91E7CDEC6D03

FASTA32235,629
        10         20         30         40         50         60 
MEIFDYDNVL LLPRKCRVRS RSECDTSVRL GERSFRIPVV PANMKTVVDE KICAWMAQNG 

        70         80         90        100        110        120 
YFYVMHRFDL DNVRFVRDMQ ARGCYASISL GVQPPDHDTV EQLAAQRITP EYITIDIAHG 

       130        140        150        160        170        180 
HADSVQEMIN RIKTRLPRAF VIAGNVATPE AVIDLENWGA DATKVGVGPG KVCITRLKTG 

       190        200        210        220        230        240 
FGTGGWQLSA LKWCARVATR PIIADGGIRS HGDIAKSIRF GASMVMVGAL LAGHEESPGQ 

       250        260        270        280        290        300 
TVEEGSERFK EYYGSASPFN KGEYKHVEGR RILEPIKGPL AHTLVEMEQD LQSSISYAGG 

       310        320 
KKLMDIRKVN YVILGGDNAV LM 

« Hide

References

[1]"Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EF01-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000542 Genomic DNA. Translation: ABM57450.1.
RefSeqYP_996468.1. NC_008786.1.

3D structure databases

ProteinModelPortalA1WIJ3.
SMRA1WIJ3. Positions 3-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391735.Veis_1695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM57450; ABM57450; Veis_1695.
GeneID4691844.
KEGGvei:Veis_1695.
PATRIC24016955. VBIVerEis120356_1876.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHOG000165753.
KOK00364.
OMAPDYITID.
OrthoDBEOG6GTZPV.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycVEIS391735:GHY5-1708-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01511. GMP_reduct_type2.
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_VEREI
AccessionPrimary (citable) accession number: A1WIJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families