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A1WIH0

- TRMB_VEREI

UniProt

A1WIH0 - TRMB_VEREI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation
Binding sitei131 – 1311S-adenosyl-L-methionineUniRule annotation
Binding sitei158 – 1581S-adenosyl-L-methionineUniRule annotation
Active sitei181 – 1811By similarity
Binding sitei181 – 1811S-adenosyl-L-methionineUniRule annotation
Binding sitei185 – 1851SubstrateUniRule annotation
Binding sitei217 – 2171SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-1685-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Veis_1672
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274tRNA (guanine-N(7)-)-methyltransferasePRO_0000288248Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391735.Veis_1672.

Structurei

3D structure databases

ProteinModelPortaliA1WIH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 2554Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiRERANAK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WIH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKLQWPIV TELTTASASR GAATGSRGVA PAVPRGGAPA DVAHPQTIKS
60 70 80 90 100
FVRRAGRTTA AQARAFEDLG PRFVVPYAPI APIAPIAPAA PAAGAWFGRD
110 120 130 140 150
APLVLEIGFG MGEATAHIAR VRPQDDFLCC EVHRPGVGAL LKRIAEHGLT
160 170 180 190 200
NIRILEHDAV EVIDHMLPES CLAGVHIFFP DPWHKSRHHK RRLIQPPLVA
210 220 230 240 250
RLAARLQAGG YLHCATDWQP YAEQMLQVLG AEPLLRNTAP GFAPKPGYRP
260 270
LTKFENRGLR LGHGVRDLVF ERRH
Length:274
Mass (Da):29,763
Last modified:February 6, 2007 - v1
Checksum:iFA0B9199B1039C70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM57427.1.
RefSeqiWP_011809434.1. NC_008786.1.
YP_996445.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM57427; ABM57427; Veis_1672.
GeneIDi4691171.
KEGGivei:Veis_1672.
PATRICi24016907. VBIVerEis120356_1852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM57427.1 .
RefSeqi WP_011809434.1. NC_008786.1.
YP_996445.1. NC_008786.1.

3D structure databases

ProteinModelPortali A1WIH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_1672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM57427 ; ABM57427 ; Veis_1672 .
GeneIDi 4691171.
KEGGi vei:Veis_1672.
PATRICi 24016907. VBIVerEis120356_1852.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi RERANAK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci VEIS391735:GHY5-1685-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiTRMB_VEREI
AccessioniPrimary (citable) accession number: A1WIH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3