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A1WHV5

- LPXB_VEREI

UniProt

A1WHV5 - LPXB_VEREI

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Veis_1451
Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-1463-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Veis_1451
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049424Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391735.Veis_1451.

Structurei

3D structure databases

ProteinModelPortaliA1WHV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiIAGQSHT.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1WHV5-1 [UniParc]FASTAAdd to Basket

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MDPAMQAPLR IAMVAGEASG DMLAALLIGG LQADWPGIEL CGIGGPEMAR    50
RGFTPWWPSE RLAVHGYSMQ MLRRLRELLG IRRQLRRRLL AHRPALFIGI 100
DAPDFNLGLE ADLRAAGVKT VHFVCPSIWA WRAHRVGQIR RSADHVLCIF 150
PFEPALLAQH GIAATYVGHP LAALIALQPD RAAARAQLGL RADDEVLAIL 200
PGSRASEIEY LARPFFQAAA LLRQTRPALK LLVPAVLPLR ERIVQAAQAA 250
GMGEQVQIIA GQSHTVLAAC DATLIASGTA TLEAALFKRP MVIAYRMHPL 300
NWSLMRRQQL QPWVGLPNIL CREFVVPELL QDAATPQALC AATQHWLDAR 350
RQHPPTITAL ERRFTALHHS LQRNTPQLAA DALRTILAH 389
Length:389
Mass (Da):42,802
Last modified:February 6, 2007 - v1
Checksum:iF4E433216C464CE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM57212.1.
RefSeqiWP_011809219.1. NC_008786.1.
YP_996230.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM57212; ABM57212; Veis_1451.
GeneIDi4690610.
KEGGivei:Veis_1451.
PATRICi24016407. VBIVerEis120356_1603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM57212.1 .
RefSeqi WP_011809219.1. NC_008786.1.
YP_996230.1. NC_008786.1.

3D structure databases

ProteinModelPortali A1WHV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_1451.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM57212 ; ABM57212 ; Veis_1451 .
GeneIDi 4690610.
KEGGi vei:Veis_1451.
PATRICi 24016407. VBIVerEis120356_1603.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi IAGQSHT.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci VEIS391735:GHY5-1463-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiLPXB_VEREI
AccessioniPrimary (citable) accession number: A1WHV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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