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A1WGU0

- SYL_VEREI

UniProt

A1WGU0 - SYL_VEREI

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei654 – 6541ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-1082-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Veis_1071
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Leucine--tRNA ligasePRO_1000009460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391735.Veis_1071.

Structurei

3D structure databases

ProteinModelPortaliA1WGU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi651 – 6555"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WGU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYSPQDI ERAAQDDWRA RDAYRVTQDA GKKKFYACSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND MLTRYLRMNG YNVLMPMGWD AFGLPAENAA IKNGMPPARW
110 120 130 140 150
TRENIAYMKQ QMQALGLAID WSRELATCDP GYYKWNQWLF LKMLDKGIAY
160 170 180 190 200
RKTQVVNWDP VDQTVLANEQ VNEGKGWRTG AVVEKREIPG YYLKITDYAE
210 220 230 240 250
ELLAFVTDDR LPGWPERVKL MQENWIGKSE GLRFAFPHDV RGDDGALIGG
260 270 280 290 300
GRLYVFTTRA DTIMGVTFCA VAPEHPLASH AAKSNPALAA FIDECRSGGT
310 320 330 340 350
TEAALATQEK KGLRTGLYVT HPLTDEPLEV WVGNYVLMGY GDGAVMGVPA
360 370 380 390 400
HDERDFAFAL KYGIEIRQVV LVDGEHFDYR RWQDWYGDKQ RGVTINSDSF
410 420 430 440 450
SGLHHKEAVQ AVAHVLEQKG LGEKKTTWRL RDWGVSRQRY WGTPIPIIHC
460 470 480 490 500
DQHGAVPVPE KDLPVVLPQD CIPDGTGNPL HSHQGFHAGV TCPVCGKSAR
510 520 530 540 550
RETDTMDTFV DSAWYFMRYC DPKNDQAMVA EGTDYWMRDP QQATGGSGMD
560 570 580 590 600
QYIGGIEHAI LHLLYARFWT KVMRDLGLVK VDEPFNRLLT QGMVLNHIYS
610 620 630 640 650
RRNDNGGREY FWPQDVEQVH DAAGKIIGAR LIRAVGDWPA GSAIDYEGMG
660 670 680 690 700
TMSKSRNNGV DPQELIGKYG ADTARLHTMF TAPPEAALEW NDAAVEGSHR
710 720 730 740 750
FLRRVWNFGL QLHAAGMTAA SASLAGAGAP QTRNPPAFGK PAKALRREIH
760 770 780 790 800
QLLRQVDYDY QRMQYNTVVS GAMKMLNALE NFKASDPASQ ASDPLALTEG
810 820 830 840 850
FGILLRCLYP VTPHIAHSLW RDLGYAAAVG ELLDAPWPQV DGQALVQDEI
860 870 880 890 900
ELMLQINGKL RGSILVPAQA SQAAIERIAR ASPAALAAGA VPKRVIVVPG

RLVNLVF
Length:907
Mass (Da):101,177
Last modified:February 6, 2007 - v1
Checksum:i2515C1206D9A9CB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000542 Genomic DNA. Translation: ABM56847.1.
RefSeqiYP_995865.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM56847; ABM56847; Veis_1071.
GeneIDi4694883.
KEGGivei:Veis_1071.
PATRICi24015599. VBIVerEis120356_1195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000542 Genomic DNA. Translation: ABM56847.1 .
RefSeqi YP_995865.1. NC_008786.1.

3D structure databases

ProteinModelPortali A1WGU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_1071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM56847 ; ABM56847 ; Veis_1071 .
GeneIDi 4694883.
KEGGi vei:Veis_1071.
PATRICi 24015599. VBIVerEis120356_1195.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci VEIS391735:GHY5-1082-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiSYL_VEREI
AccessioniPrimary (citable) accession number: A1WGU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3