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A1WGU0

- SYL_VEREI

UniProt

A1WGU0 - SYL_VEREI

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Protein
Leucine--tRNA ligase
Gene
leuS, Veis_1071
Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei654 – 6541ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVEIS391735:GHY5-1082-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Veis_1071
OrganismiVerminephrobacter eiseniae (strain EF01-2)
Taxonomic identifieri391735 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
ProteomesiUP000000374: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Leucine--tRNA ligaseUniRule annotation
PRO_1000009460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391735.Veis_1071.

Structurei

3D structure databases

ProteinModelPortaliA1WGU0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi651 – 6555"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WGU0-1 [UniParc]FASTAAdd to Basket

« Hide

MQDKYSPQDI ERAAQDDWRA RDAYRVTQDA GKKKFYACSM LPYPSGKLHM    50
GHVRNYTIND MLTRYLRMNG YNVLMPMGWD AFGLPAENAA IKNGMPPARW 100
TRENIAYMKQ QMQALGLAID WSRELATCDP GYYKWNQWLF LKMLDKGIAY 150
RKTQVVNWDP VDQTVLANEQ VNEGKGWRTG AVVEKREIPG YYLKITDYAE 200
ELLAFVTDDR LPGWPERVKL MQENWIGKSE GLRFAFPHDV RGDDGALIGG 250
GRLYVFTTRA DTIMGVTFCA VAPEHPLASH AAKSNPALAA FIDECRSGGT 300
TEAALATQEK KGLRTGLYVT HPLTDEPLEV WVGNYVLMGY GDGAVMGVPA 350
HDERDFAFAL KYGIEIRQVV LVDGEHFDYR RWQDWYGDKQ RGVTINSDSF 400
SGLHHKEAVQ AVAHVLEQKG LGEKKTTWRL RDWGVSRQRY WGTPIPIIHC 450
DQHGAVPVPE KDLPVVLPQD CIPDGTGNPL HSHQGFHAGV TCPVCGKSAR 500
RETDTMDTFV DSAWYFMRYC DPKNDQAMVA EGTDYWMRDP QQATGGSGMD 550
QYIGGIEHAI LHLLYARFWT KVMRDLGLVK VDEPFNRLLT QGMVLNHIYS 600
RRNDNGGREY FWPQDVEQVH DAAGKIIGAR LIRAVGDWPA GSAIDYEGMG 650
TMSKSRNNGV DPQELIGKYG ADTARLHTMF TAPPEAALEW NDAAVEGSHR 700
FLRRVWNFGL QLHAAGMTAA SASLAGAGAP QTRNPPAFGK PAKALRREIH 750
QLLRQVDYDY QRMQYNTVVS GAMKMLNALE NFKASDPASQ ASDPLALTEG 800
FGILLRCLYP VTPHIAHSLW RDLGYAAAVG ELLDAPWPQV DGQALVQDEI 850
ELMLQINGKL RGSILVPAQA SQAAIERIAR ASPAALAAGA VPKRVIVVPG 900
RLVNLVF 907
Length:907
Mass (Da):101,177
Last modified:February 6, 2007 - v1
Checksum:i2515C1206D9A9CB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM56847.1.
RefSeqiWP_011808858.1. NC_008786.1.
YP_995865.1. NC_008786.1.

Genome annotation databases

EnsemblBacteriaiABM56847; ABM56847; Veis_1071.
GeneIDi4694883.
KEGGivei:Veis_1071.
PATRICi24015599. VBIVerEis120356_1195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000542 Genomic DNA. Translation: ABM56847.1 .
RefSeqi WP_011808858.1. NC_008786.1.
YP_995865.1. NC_008786.1.

3D structure databases

ProteinModelPortali A1WGU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391735.Veis_1071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM56847 ; ABM56847 ; Veis_1071 .
GeneIDi 4694883.
KEGGi vei:Veis_1071.
PATRICi 24015599. VBIVerEis120356_1195.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci VEIS391735:GHY5-1082-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EF01-2.

Entry informationi

Entry nameiSYL_VEREI
AccessioniPrimary (citable) accession number: A1WGU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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