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A1WGU0

- SYL_VEREI

UniProt

A1WGU0 - SYL_VEREI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Verminephrobacter eiseniae (strain EF01-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei654 – 6541ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVEIS391735:GHY5-1082-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Veis_1071
    OrganismiVerminephrobacter eiseniae (strain EF01-2)
    Taxonomic identifieri391735 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeVerminephrobacter
    ProteomesiUP000000374: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 907907Leucine--tRNA ligasePRO_1000009460Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391735.Veis_1071.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WGU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi651 – 6555"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1WGU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYSPQDI ERAAQDDWRA RDAYRVTQDA GKKKFYACSM LPYPSGKLHM    50
    GHVRNYTIND MLTRYLRMNG YNVLMPMGWD AFGLPAENAA IKNGMPPARW 100
    TRENIAYMKQ QMQALGLAID WSRELATCDP GYYKWNQWLF LKMLDKGIAY 150
    RKTQVVNWDP VDQTVLANEQ VNEGKGWRTG AVVEKREIPG YYLKITDYAE 200
    ELLAFVTDDR LPGWPERVKL MQENWIGKSE GLRFAFPHDV RGDDGALIGG 250
    GRLYVFTTRA DTIMGVTFCA VAPEHPLASH AAKSNPALAA FIDECRSGGT 300
    TEAALATQEK KGLRTGLYVT HPLTDEPLEV WVGNYVLMGY GDGAVMGVPA 350
    HDERDFAFAL KYGIEIRQVV LVDGEHFDYR RWQDWYGDKQ RGVTINSDSF 400
    SGLHHKEAVQ AVAHVLEQKG LGEKKTTWRL RDWGVSRQRY WGTPIPIIHC 450
    DQHGAVPVPE KDLPVVLPQD CIPDGTGNPL HSHQGFHAGV TCPVCGKSAR 500
    RETDTMDTFV DSAWYFMRYC DPKNDQAMVA EGTDYWMRDP QQATGGSGMD 550
    QYIGGIEHAI LHLLYARFWT KVMRDLGLVK VDEPFNRLLT QGMVLNHIYS 600
    RRNDNGGREY FWPQDVEQVH DAAGKIIGAR LIRAVGDWPA GSAIDYEGMG 650
    TMSKSRNNGV DPQELIGKYG ADTARLHTMF TAPPEAALEW NDAAVEGSHR 700
    FLRRVWNFGL QLHAAGMTAA SASLAGAGAP QTRNPPAFGK PAKALRREIH 750
    QLLRQVDYDY QRMQYNTVVS GAMKMLNALE NFKASDPASQ ASDPLALTEG 800
    FGILLRCLYP VTPHIAHSLW RDLGYAAAVG ELLDAPWPQV DGQALVQDEI 850
    ELMLQINGKL RGSILVPAQA SQAAIERIAR ASPAALAAGA VPKRVIVVPG 900
    RLVNLVF 907
    Length:907
    Mass (Da):101,177
    Last modified:February 6, 2007 - v1
    Checksum:i2515C1206D9A9CB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM56847.1.
    RefSeqiWP_011808858.1. NC_008786.1.
    YP_995865.1. NC_008786.1.

    Genome annotation databases

    EnsemblBacteriaiABM56847; ABM56847; Veis_1071.
    GeneIDi4694883.
    KEGGivei:Veis_1071.
    PATRICi24015599. VBIVerEis120356_1195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000542 Genomic DNA. Translation: ABM56847.1 .
    RefSeqi WP_011808858.1. NC_008786.1.
    YP_995865.1. NC_008786.1.

    3D structure databases

    ProteinModelPortali A1WGU0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391735.Veis_1071.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM56847 ; ABM56847 ; Veis_1071 .
    GeneIDi 4694883.
    KEGGi vei:Veis_1071.
    PATRICi 24015599. VBIVerEis120356_1195.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci VEIS391735:GHY5-1082-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EF01-2.

    Entry informationi

    Entry nameiSYL_VEREI
    AccessioniPrimary (citable) accession number: A1WGU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3