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A1WEE3 (A1WEE3_VEREI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099
Gene names
Ordered Locus Names:Veis_0208
OrganismVerminephrobacter eiseniae (strain EF01-2) [Complete proteome] [HAMAP]
Taxonomic identifier391735 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Verminephrobacter

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS001692

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS001692

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS001692

Sequence similarities

Belongs to the histidinol dehydrogenase family. PIRNR PIRNR000099 RuleBase RU004175

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3441Proton acceptor By similarity PIRSR PIRSR000099-1
Active site3451Proton acceptor By similarity PIRSR PIRSR000099-1

Sequences

Sequence LengthMass (Da)Tools
A1WEE3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 7F781CEA3C66084E

FASTA45948,792
        10         20         30         40         50         60 
MTHRIDHGFK AMKSINLIEL SKLSPQQRKS LMLRTESDLS TYANAVLPII EDVRNRGDAA 

        70         80         90        100        110        120 
LVHYAAQFEG AAIGLDSIRV SPAEFDAAFA MLDPKVVAAI EYGIENIRSF HTAQKPVQYW 

       130        140        150        160        170        180 
MKELRPGAFA GERITPIDTV ALYVPRGKGS FPSTVMMLCV PAVVAQVPTA YILTPAGPDG 

       190        200        210        220        230        240 
RVDAATLVAA RLAGIETIFK VGGSQAVAAA AFGTSTIPKA DKILGPGSPW VMAAKRALVD 

       250        260        270        280        290        300 
HLDPGIPAGP SESIVFADAS ADARLAALDV LIEAEHGPDS SAFLVTTSRA IASAAIDWIA 

       310        320        330        340        350        360 
HFWNEMSARR VEFSATVLTG PRGGVLLADS VPSAMDFIND YAPEHLEILG AEPFGYLHQI 

       370        380        390        400        410        420 
RNAGEILLGH ATPMSIANFV LGPNAVLPTS FGAKTVSALS VHDFIKRTSI GYVTTKAFPP 

       430        440        450 
MAAMGRELAI YEGFDAHALA LAPQRFDPPV ARTQPMAAE

« Hide

References

[1]"Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EF01-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000542 Genomic DNA. Translation: ABM56000.1.
RefSeqYP_995018.2. NC_008786.1.

3D structure databases

ProteinModelPortalA1WEE3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1WEE3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4695126.
GenomeReviewsGene locus Veis_0208 in contig CP000542_GR.
KEGGvei:Veis_0208.
NMPDRfig|391735.5.peg.225.
PATRIC24013700. VBIVerEis120356_0255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHBG329596.
OMAKIVGPGS.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycVEIS391735:VEIS_0208-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1WEE3_VEREI
AccessionPrimary (citable) accession number: A1WEE3
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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