Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1WCP8

- SYL_ACISJ

UniProt

A1WCP8 - SYL_ACISJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei661 – 6611ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASP232721:GHWE-3980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ajs_3917
    OrganismiAcidovorax sp. (strain JS42)
    Taxonomic identifieri232721 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
    ProteomesiUP000000645: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 910910Leucine--tRNA ligasePRO_1000009285Add
    BLAST

    Proteomic databases

    PRIDEiA1WCP8.

    Interactioni

    Protein-protein interaction databases

    STRINGi232721.Ajs_3917.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WCP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi658 – 6625"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1WCP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYNHTEV ERAAHAHWNA NDAYRVTEDQ AKPKFYACSM LPYPSGKLHM    50
    GHVRNYTIND MLTRSLRMKG HNVLMPMGWD AFGLPAENAA LKNGVPPAQW 100
    TYDNIAYMKK QMQAMGLAID WSREIATCDP DYYKWNQWLF LKMLDKGIAY 150
    RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG ALVEKREIPG YYLKITDYAQ 200
    ELLDHVQIGN EKATLTGWPD KVRLMQENWI GKSAGVRFAF PHDIRNAAGE 250
    RIQDGKLYVF TTRADTIMGV TFCAVAPEHP LAQHAAASNA ALAAFIEECK 300
    KGGTTEAELA LKEKEGMPTG LFVTHPLTGE QVEVWVGNYV LMSYGDGAVM 350
    GVPAHDERDF AFALKYQLPI KQVVLVDGET FDFHQWQDWY GDKERGVTIN 400
    SGNFSGLSYQ DAVAAVAHAL AEKGLGELKT TWRLRDWGIS RQRYWGTPIP 450
    IIHCESCGAV PVPEKDLPVV LPQDLVPDGS GNPLAKCEAF LKVDCPCCGK 500
    PARRETDTMD TFVDSSWYFM RYCDPKNRDA MVAGGTDYWM RDQKAATGGS 550
    GMDQYIGGIE HAILHLLYAR FWTKVMRDLG LVKVDEPFTK LLTQGMVLNH 600
    IYSRRTAKGA KDYFWPHDVE HVYDEAGKIV GAKLKNPAES GDGLLPVGTP 650
    IDYEGVGTMS KSKNNGVDPQ QLIEKYGADT ARLYTMFTAP PELTLEWNDA 700
    AVEGSYRFLR RVWNFGVKLS AIDKDAALAS VAGAASLKDV QFGKEAKALR 750
    LEIHTVLKQV DYDYQRMQYN TVVSGAMKMI NALEDFKATD SAGAQVALIE 800
    GFGILLRVLY PATPHIAHVL WDELGYAGTL GDLLDAAWPQ VAPDALVQDE 850
    LELMLQVNGK LRGAIRVAAS ADKAAIEQAA LASEDFHKFA EGKAPKKVII 900
    VPGRLVNVVV 910
    Length:910
    Mass (Da):101,205
    Last modified:February 6, 2007 - v1
    Checksum:iC0549663194C215C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000539 Genomic DNA. Translation: ABM44023.1.
    RefSeqiWP_011807003.1. NC_008782.1.
    YP_988099.1. NC_008782.1.

    Genome annotation databases

    EnsemblBacteriaiABM44023; ABM44023; Ajs_3917.
    GeneIDi4673423.
    KEGGiajs:Ajs_3917.
    PATRICi20693275. VBIAciSp27161_4138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000539 Genomic DNA. Translation: ABM44023.1 .
    RefSeqi WP_011807003.1. NC_008782.1.
    YP_988099.1. NC_008782.1.

    3D structure databases

    ProteinModelPortali A1WCP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 232721.Ajs_3917.

    Proteomic databases

    PRIDEi A1WCP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM44023 ; ABM44023 ; Ajs_3917 .
    GeneIDi 4673423.
    KEGGi ajs:Ajs_3917.
    PATRICi 20693275. VBIAciSp27161_4138.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ASP232721:GHWE-3980-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JS42.

    Entry informationi

    Entry nameiSYL_ACISJ
    AccessioniPrimary (citable) accession number: A1WCP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3