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A1WCP8

- SYL_ACISJ

UniProt

A1WCP8 - SYL_ACISJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei661 – 6611ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP232721:GHWE-3980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ajs_3917
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000645: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Leucine--tRNA ligasePRO_1000009285Add
BLAST

Proteomic databases

PRIDEiA1WCP8.

Interactioni

Protein-protein interaction databases

STRINGi232721.Ajs_3917.

Structurei

3D structure databases

ProteinModelPortaliA1WCP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi658 – 6625"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WCP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYNHTEV ERAAHAHWNA NDAYRVTEDQ AKPKFYACSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND MLTRSLRMKG HNVLMPMGWD AFGLPAENAA LKNGVPPAQW
110 120 130 140 150
TYDNIAYMKK QMQAMGLAID WSREIATCDP DYYKWNQWLF LKMLDKGIAY
160 170 180 190 200
RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG ALVEKREIPG YYLKITDYAQ
210 220 230 240 250
ELLDHVQIGN EKATLTGWPD KVRLMQENWI GKSAGVRFAF PHDIRNAAGE
260 270 280 290 300
RIQDGKLYVF TTRADTIMGV TFCAVAPEHP LAQHAAASNA ALAAFIEECK
310 320 330 340 350
KGGTTEAELA LKEKEGMPTG LFVTHPLTGE QVEVWVGNYV LMSYGDGAVM
360 370 380 390 400
GVPAHDERDF AFALKYQLPI KQVVLVDGET FDFHQWQDWY GDKERGVTIN
410 420 430 440 450
SGNFSGLSYQ DAVAAVAHAL AEKGLGELKT TWRLRDWGIS RQRYWGTPIP
460 470 480 490 500
IIHCESCGAV PVPEKDLPVV LPQDLVPDGS GNPLAKCEAF LKVDCPCCGK
510 520 530 540 550
PARRETDTMD TFVDSSWYFM RYCDPKNRDA MVAGGTDYWM RDQKAATGGS
560 570 580 590 600
GMDQYIGGIE HAILHLLYAR FWTKVMRDLG LVKVDEPFTK LLTQGMVLNH
610 620 630 640 650
IYSRRTAKGA KDYFWPHDVE HVYDEAGKIV GAKLKNPAES GDGLLPVGTP
660 670 680 690 700
IDYEGVGTMS KSKNNGVDPQ QLIEKYGADT ARLYTMFTAP PELTLEWNDA
710 720 730 740 750
AVEGSYRFLR RVWNFGVKLS AIDKDAALAS VAGAASLKDV QFGKEAKALR
760 770 780 790 800
LEIHTVLKQV DYDYQRMQYN TVVSGAMKMI NALEDFKATD SAGAQVALIE
810 820 830 840 850
GFGILLRVLY PATPHIAHVL WDELGYAGTL GDLLDAAWPQ VAPDALVQDE
860 870 880 890 900
LELMLQVNGK LRGAIRVAAS ADKAAIEQAA LASEDFHKFA EGKAPKKVII
910
VPGRLVNVVV
Length:910
Mass (Da):101,205
Last modified:February 6, 2007 - v1
Checksum:iC0549663194C215C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM44023.1.
RefSeqiWP_011807003.1. NC_008782.1.
YP_988099.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM44023; ABM44023; Ajs_3917.
GeneIDi4673423.
KEGGiajs:Ajs_3917.
PATRICi20693275. VBIAciSp27161_4138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM44023.1 .
RefSeqi WP_011807003.1. NC_008782.1.
YP_988099.1. NC_008782.1.

3D structure databases

ProteinModelPortali A1WCP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 232721.Ajs_3917.

Proteomic databases

PRIDEi A1WCP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM44023 ; ABM44023 ; Ajs_3917 .
GeneIDi 4673423.
KEGGi ajs:Ajs_3917.
PATRICi 20693275. VBIAciSp27161_4138.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ASP232721:GHWE-3980-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS42.

Entry informationi

Entry nameiSYL_ACISJ
AccessioniPrimary (citable) accession number: A1WCP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3