Reviewed, UniProtKB/Swiss-Prot A1WCJ3 (DCUP_ACISJ)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Ajs_3861

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023866
Regions
	Region	29 – 33	5	Substrate binding By similarity
Sites
	Binding site	79	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	342	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1WCJ3-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 42F197052F743C98	FASTA	370	40,219
	10 20 30 40 50 60 MSFAPLQNDT FLRACRRQAT DYTPLWLMRQ AGRYLPEYKA TRAKAGSFMG LATNVEYATE 70 80 90 100 110 120 VTLQPLERFP LDAAILFSDI LTVPDAMGLG LSFAEGEGPR FAKAVRDEAD VAALAVPDLD 130 140 150 160 170 180 KLRYVFDAVT SIRRALNGRV PLIGFSGSPW TLACYMVEGK GSDDYRLVKT LMYSRPDLMH 190 200 210 220 230 240 RILAVNADAV AAYLNAQIDA GAQAVMVFDS WGGVLADGCF QQFSLEYTRR VLAQLKRTGV 250 260 270 280 290 300 DGQDVPRIVF TKGGGIWLDD MKDIDCEVLG LDWTAHLGKA RAIVGGQVGG PGKALQGNID 310 320 330 340 350 360 PNVLFAPPEA VAAQVRAVLD SFGTPHTDKT TTGPTHIFNL GHGISQFTPP EHVAALVEAV 370 HGYSRSLRQR

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000539 Genomic DNA. Translation: ABM43968.1.
RefSeq	YP_988044.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1WCJ3.
Genome annotation databases
GeneID	4671255.
GenomeReviews	Gene locus Ajs_3861 in contig CP000539_GR.
KEGG	ajs:Ajs_3861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VFTKGGG.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_ACISJ

Accession

Primary (citable) accession number: A1WCJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)