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A1WC09 (MRAY_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Ajs_3673
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002929

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane369 – 38921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1WC09 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 4B2AC153E0AA511D

FASTA39243,099
        10         20         30         40         50         60 
MLLMLTQWLQ GLSPELSFLR VFQYLTLRAV MAALTALLIG LIAGPKVIRM LTSLKIGQPI 

        70         80         90        100        110        120 
RGYAMQTHLS KSGTPTMGGV LILGSIAIST LLWFDLSNRF VWIVLAVTLG FGAIGWVDDW 

       130        140        150        160        170        180 
RKVVNKDPEG MRSREKYFWQ SVIGLLAALY LVFSISENSN TRVFELFITW VQSGFLMDLP 

       190        200        210        220        230        240 
PKAGLLVPFF KEVSYPLGVL GFVILTYLVI VGSSNAVNLT DGLDGLAIMP VIMVGASLGI 

       250        260        270        280        290        300 
FAYVTGNAGY AKYLLFPYIA GSGELLIFCA AMAGAGLAFL WFNTHPAQVF MGDVGALALG 

       310        320        330        340        350        360 
AALGTIAVIV RQEIVLAIMG GIFVVEALSV MLQVTWFKYT KRKYGEGRRL LKMAPLHHHF 

       370        380        390 
EKSGWKETQV VVRFWIITML LCLVGLTTLK LR

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM43784.1.
RefSeqYP_987860.1. NC_008782.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1WC09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4673624.
GenomeReviewsGene locus Ajs_3673 in contig CP000539_GR.
KEGGajs:Ajs_3673.
PATRIC20692743. VBIAciSp27161_3887.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
PhylomeDBA1WC09.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycASP232721:AJS_3673-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACISJ
AccessionPrimary (citable) accession number: A1WC09
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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