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A1WC06 (MURG_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:Ajs_3670
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000315059

Sequences

Sequence LengthMass (Da)Tools
A1WC06 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: FDFAAC35F10C843D

FASTA39943,251
        10         20         30         40         50         60 
MTSRFGHSQH PRRGRSARAR AGRREGVQSN FPATQVLERS AHSLPARQRT ALVMAGGTGG 

        70         80         90        100        110        120 
HIFPGLALAE ALRERGWQVH WLGTPGSMEE RLVPPRGFAF EPIDFSGVRG KGLKTLLALP 

       130        140        150        160        170        180 
LRLARACLQA RAVVRRLQPD VVIGLGGYVT FPGGIAARLA RKPLLLHEQN SVPGMANKLL 

       190        200        210        220        230        240 
SRLATRVYTA FPNVLPDAQW VGNPMRRAFT RQPRPERRLA GREGPLRLLV VGGSLGAKAL 

       250        260        270        280        290        300 
NDIVPQALAW IHEQDRPIVT HQSGESQIEA LRRSYAAAGV EATLTPFIED TAAAFAEADL 

       310        320        330        340        350        360 
VLCRAGASTV TEIAAVGAAA VFVPFPHAVD DHQTTNAQYL VKVGGGWLVQ QADLTAHGLA 

       370        380        390 
EMLQNMKRQD LLAKAQKART MRKINATRDI VAACERLAR

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM43781.1.
RefSeqYP_987857.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1WC06.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1WC06.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4673642.
GenomeReviewsGene locus Ajs_3670 in contig CP000539_GR.
KEGGajs:Ajs_3670.
PATRIC20692735. VBIAciSp27161_3883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBA1WC06.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycASP232721:AJS_3670-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_ACISJ
AccessionPrimary (citable) accession number: A1WC06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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