Reviewed, UniProtKB/Swiss-Prot A1WBZ2 (AROE_ACISJ)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Ajs_3656

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325092
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A1WBZ2-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 19E590583AB8AC4B	FASTA	282	29,114
	10 20 30 40 50 60 MTAAADLYCV MGNPIAHSRS PWIHARFAQL TGQSLHYERR LVPLDGFAQA LQSFAAEGGR 70 80 90 100 110 120 GCNITVPFKL EAAQLATTRS ERVQLAGAAN TLVFDGGSIH ADNTDGLGLV ADITQGAGVP 130 140 150 160 170 180 LAGRDVLLVG AGGAAAGVLG PLLRQHPRRI AVVNRTPARA QALVDSHAAL AALQKTELLA 190 200 210 220 230 240 LDMQAPGADF DVIINATASS LEGGPVPVPA SVLRPGSLAY DMMYGPAAQP FLDWATGHGA 250 260 270 280 TARDGLGMLV EQAAEAFLLW RGVRPPSAPV LQELRAAIAA GA

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000539 Genomic DNA. Translation: ABM43767.1.
RefSeq	YP_987843.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1WBZ2.
Genome annotation databases
GeneID	4674125.
GenomeReviews	Gene locus Ajs_3656 in contig CP000539_GR.
KEGG	ajs:Ajs_3656.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HGATARD.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ACISJ

Accession

Primary (citable) accession number: A1WBZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)