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A1WB23 (GUAC_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Ajs_3326
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325GMP reductase HAMAP MF_01511
PRO_0000294270

Regions

Nucleotide binding202 – 22524NADP Potential

Sites

Active site1731Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1WB23 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 93B64E736912B803

FASTA32535,771
        10         20         30         40         50         60 
MEIFDYDNIL LLPRKCRVES RSECDTSVEL GERRFRLPVV PANMKTVVDE KICTWLAQNG 

        70         80         90        100        110        120 
YFYVMHRFDL DNVQFVKDMH AQGCFASISL GVKQPDYDTV DRFVAEGICP EYITIDIAHG 

       130        140        150        160        170        180 
HADSVKNMIT YLKAKIPAAF VIAGNVGTPE AVIDLENWGA DATKVGIGPG KVCITKLKTG 

       190        200        210        220        230        240 
FGTGGWQLSA LKWCARVATK PIIADGGIRS HGDIAKSVRF GATMVMVGSL FAGHEESPGK 

       250        260        270        280        290        300 
TVEVDGELYK EYYGSASDFN KGEYKHVEGK RILEPIKGKL ADTLTEMEQD IQSSISYSGG 

       310        320 
KKLMDIRKVN YVILGGDNAG EHLLM

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM43448.1.
RefSeqYP_987524.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1WB23.
SMRA1WB23. Positions 3-314.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1WB23.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4670813.
GenomeReviewsGene locus Ajs_3326 in contig CP000539_GR.
KEGGajs:Ajs_3326.
PATRIC20692023. VBIAciSp27161_3531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHBG298985.
OMAPDYITID.
PhylomeDBA1WB23.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycASP232721:AJS_3326-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_ACISJ
AccessionPrimary (citable) accession number: A1WB23
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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