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A1WB09 (ARLY_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Ajs_3312
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Argininosuccinate lyase HAMAP MF_00006
PRO_0000321425

Sequences

Sequence LengthMass (Da)Tools
A1WB09 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 055B9DE600372EBA

FASTA48653,015
        10         20         30         40         50         60 
MSSSSASQPS HDQLATKAQA WSALFSEPMS DLVKRYTSSV FFDKRLWQAD IAGSLAHAEM 

        70         80         90        100        110        120 
LAAQGIISAQ DHADIQKGMA QITQEIASGA FEWKLDLEDV HLNIEARLTQ LVGDAGKRLH 

       130        140        150        160        170        180 
TGRSRNDQVA TDVRLWLRGE IDLIEGLLSE LQLSLVEVAE QNVEVILPGF THLQVAQPVS 

       190        200        210        220        230        240 
FAHHLLAYVE MFARDAERMR DVRRRVNVLP LGSAALAGTT YPLDRERVAK TLGMEGVCQN 

       250        260        270        280        290        300 
SLDGVSDRDF AIEFTAAASL CMVHVSRLSE ELIIWMSQNF GFIKIADRFT TGSSIMPQKK 

       310        320        330        340        350        360 
NPDVPELARG KTGRVVGHLM GLITLMKGQP LAYNKDNQED KEPLFDTVDT LKDTLRIFAE 

       370        380        390        400        410        420 
MIGGQMNPAT GCKDGGITVN AEAMRAAALK GYATATDLAD YLVKKGLPFR DAHETVAHAV 

       430        440        450        460        470        480 
KAAVSHSVDL SELPLAVLQG FHPAIEKDVF DALSLQGSLN ARNTLGGTAP AQVRTQLARH 


RARLSA

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM43434.1.
RefSeqYP_987510.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1WB09.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1WB09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4671568.
GenomeReviewsGene locus Ajs_3312 in contig CP000539_GR.
KEGGajs:Ajs_3312.
PATRIC20691995. VBIAciSp27161_3517.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBA1WB09.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycASP232721:AJS_3312-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_ACISJ
AccessionPrimary (citable) accession number: A1WB09
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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