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A1W9H6 (F16PA_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Gene names
Name:fbp
Ordered Locus Names:Ajs_2760
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855
PRO_0000364446

Regions

Region117 – 1204Substrate binding By similarity

Sites

Metal binding921Magnesium 1 By similarity
Metal binding1141Magnesium 1 By similarity
Metal binding1141Magnesium 2 By similarity
Metal binding1161Magnesium 1; via carbonyl oxygen By similarity
Metal binding1171Magnesium 2 By similarity
Metal binding2851Magnesium 2 By similarity
Binding site2131Substrate By similarity
Binding site2791Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1W9H6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: F297067C785EEED2

FASTA33938,014
        10         20         30         40         50         60 
MTERISLTRY LVEQQRVHGR IPPQLRLLVE VVARACKRIS FAVNKGDLGD VMGTAGTENV 

        70         80         90        100        110        120 
QGEVQKKLDI IANEVLIEAN EWGGHLAAMA SEEMDGIYVV PNRFPQGEHL LMFDPLDGSS 

       130        140        150        160        170        180 
NIDVNVSIGT IFSVLHKHHD DPTTDEPVTE ADFLQPGHQQ VAAGYCIYGP QTTLVLTVGD 

       190        200        210        220        230        240 
GVAMFTLDRE QGSFVLTREN IRIPEDTKEF AINMSNMRHW DAPVRRYIDE CLQGKEGPRG 

       250        260        270        280        290        300 
KDFNMRWIAS MVADVHRILM RGGIFMYPWD KREPNKPGKL RLMYEANPMG WLVEQAGGAA 

       310        320        330 
TNGRQRILDI QPAQLHERVS VILGSKNEVD RVTSYHSGI

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM42901.1.
RefSeqYP_986977.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1W9H6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1W9H6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4674105.
GenomeReviewsGene locus Ajs_2760 in contig CP000539_GR.
KEGGajs:Ajs_2760.
PATRIC20690871. VBIAciSp27161_2957.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0158.
HOGENOMHBG731261.
OMAHWEAPVQ.
PhylomeDBA1W9H6.
ProtClustDBPRK09293.

Enzyme and pathway databases

BioCycASP232721:AJS_2760-MONOMER.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. FBPase_class-1/SBPase.
[Graphical view]
KOK03841.
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFPIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF16PA_ACISJ
AccessionPrimary (citable) accession number: A1W9H6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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