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A1W9F9

- ASSY_ACISJ

UniProt

A1W9F9 - ASSY_ACISJ

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Protein

Argininosuccinate synthase

Gene
argG, Ajs_2743
Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATP By similarity
Binding sitei99 – 991Citrulline By similarity
Binding sitei129 – 1291ATP; via amide nitrogen By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei131 – 1311ATP By similarity
Binding sitei135 – 1351Aspartate By similarity
Binding sitei135 – 1351Citrulline By similarity
Binding sitei136 – 1361Aspartate By similarity
Binding sitei136 – 1361ATP By similarity
Binding sitei139 – 1391Citrulline By similarity
Binding sitei192 – 1921Citrulline By similarity
Binding sitei194 – 1941ATP By similarity
Binding sitei201 – 2011Citrulline By similarity
Binding sitei203 – 2031Citrulline By similarity
Binding sitei280 – 2801Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP232721:GHWE-2783-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Ajs_2743
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000645: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Argininosuccinate synthaseUniRule annotationPRO_1000025410Add
BLAST

Proteomic databases

PRIDEiA1W9F9.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi232721.Ajs_2743.

Structurei

3D structure databases

ProteinModelPortaliA1W9F9.
SMRiA1W9F9. Positions 3-442.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230094.
KOiK01940.
OMAiRIVEPIM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1W9F9-1 [UniParc]FASTAAdd to Basket

« Hide

MATILQHLPV GQKVGIAFSG GLDTSAALRW MKNKGALPYA YTANLGQPDE    50
ADYDEIPRKA MEYGAEKARL IDCRTQLAHE GIAAIQAGAF HISTGGITYF 100
NTTPLGRAVT GTMLVAAMKE DDVHIWGDGS TFKGNDIERF YRYGLLTNPA 150
LKIYKPWLDQ KFIDELGGRA EMSAFMTKEG FGYKMSAEKA YSTDSNMLGA 200
THEAKDLEFL SSGIRIVNPI MGVAFWKPEV DVPAEEVSVT FDEGQPVAVN 250
GKEIADPVEL FLELNRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
HIAYERLVTG IHNEDTIEQY RLNGLKLGRL LYQGRWFDPQ AIMLRETAQR 350
WVARAVTGTV TLELRRGNDY SILNTESPNL TYAPERLSME KVEDAPFSPL 400
DRIGQLTMRN LDISDTRGKL GVYARAGLLS LGGNAALAQL EDGGAKKK 448
Length:448
Mass (Da):49,343
Last modified:February 6, 2007 - v1
Checksum:i861CD628C346138A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM42884.1.
RefSeqiYP_986960.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM42884; ABM42884; Ajs_2743.
GeneIDi4673452.
KEGGiajs:Ajs_2743.
PATRICi20690837. VBIAciSp27161_2940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM42884.1 .
RefSeqi YP_986960.1. NC_008782.1.

3D structure databases

ProteinModelPortali A1W9F9.
SMRi A1W9F9. Positions 3-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 232721.Ajs_2743.

Proteomic databases

PRIDEi A1W9F9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM42884 ; ABM42884 ; Ajs_2743 .
GeneIDi 4673452.
KEGGi ajs:Ajs_2743.
PATRICi 20690837. VBIAciSp27161_2940.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230094.
KOi K01940.
OMAi RIVEPIM.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ASP232721:GHWE-2783-MONOMER.

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS42.

Entry informationi

Entry nameiASSY_ACISJ
AccessioniPrimary (citable) accession number: A1W9F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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