A1W908 (LPXD_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	Ajs_2575

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_1000050921
Sites
	Active site	225	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1W908 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E76038C0B534FF39	FASTA	326	34,504
	10 20 30 40 50 60 MSLRLGQIVD ALGGSLEGGE RDTEILRIAP LESSGPGDLS FLSNPRYQSQ LAASQAACVI 70 80 90 100 110 120 VAPAMRNAAL ERGACIVVEQ PYTYFAHVTQ LWVRAHGQGA PAGIHPSAVV DPQARVAPTA 130 140 150 160 170 180 SIGPLCVVER GAVIGAHTVL KSRVTVGERC TVGERCILHP GVVIGADGFG FAQQRGEWIK 190 200 210 220 230 240 IEQLGAVRIG NDVEIGANTC IDRGALDDTV IEDGVKLDNL IQIAHNVHIG RHTAMAGCSA 250 260 270 280 290 300 VAGSTRIGAH CTIAGAASIV GHLQLADNVH ISTNTVVTHS ITQPGQYTGV FPMDDNAKWE 310 320 KNAATLRQLY RLRERIKALE QTRKDG

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000539 Genomic DNA. Translation: ABM42733.1.
RefSeq	YP_986809.1. NC_008782.1.
3D structure databases
ProteinModelPortal	A1W908.
ModBase	Search...
Protein-protein interaction databases
STRING	A1W908.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4671797.
GenomeReviews	Gene locus Ajs_2575 in contig CP000539_GR.
KEGG	ajs:Ajs_2575.
PATRIC	20690507. VBIAciSp27161_2781.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	CFVGKNT.
PhylomeDB	A1W908.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	ASP232721:AJS_2575-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_ACISJ

Accession

Primary (citable) accession number: A1W908

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program