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A1W7D2

- TRMB_ACISJ

UniProt

A1W7D2 - TRMB_ACISJ

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Ajs_1981
Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091S-adenosyl-L-methionine By similarity
Binding sitei136 – 1361S-adenosyl-L-methionine By similarity
Active sitei159 – 1591 By similarity
Binding sitei159 – 1591S-adenosyl-L-methionine By similarity
Binding sitei163 – 1631Substrate By similarity
Binding sitei195 – 1951Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciASP232721:GHWE-2006-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Ajs_1981
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000645: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288113Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi232721.Ajs_1981.

Structurei

3D structure databases

ProteinModelPortaliA1W7D2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1706Interaction with RNA Reviewed prediction
Regioni230 – 2334Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiQDNFLCC.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1W7D2-1 [UniParc]FASTAAdd to Basket

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MTQTLSSQDP QAPAAPPMPG AAGSAPADVA HPKGIKSYVR RAGRTTTGQA    50
KALEELGPRY VLDYAPALLD ATAAFGRSAP LVLEIGFGMG EATAHIARVR 100
PQDNFLCCEV HEPGVGALLK RIGEQDIHNI RILQHDAVEV LEHMLAPGAL 150
DGVHIFFPDP WHKKRHNKRR LIQPPLVAQL AARLKPGGYI HCATDWQPYA 200
EQMLEVLSAE PLLSNTAEGY APQPDYRPLT KFENRGMRLG HGVWDLVFTR 250
R 251
Length:251
Mass (Da):27,506
Last modified:February 6, 2007 - v1
Checksum:i1A6DC5AB16355179
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM42157.1.
RefSeqiWP_011805225.1. NC_008782.1.
YP_986233.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM42157; ABM42157; Ajs_1981.
GeneIDi4674401.
KEGGiajs:Ajs_1981.
PATRICi20689292. VBIAciSp27161_2180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM42157.1 .
RefSeqi WP_011805225.1. NC_008782.1.
YP_986233.1. NC_008782.1.

3D structure databases

ProteinModelPortali A1W7D2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 232721.Ajs_1981.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM42157 ; ABM42157 ; Ajs_1981 .
GeneIDi 4674401.
KEGGi ajs:Ajs_1981.
PATRICi 20689292. VBIAciSp27161_2180.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi QDNFLCC.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci ASP232721:GHWE-2006-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS42.

Entry informationi

Entry nameiTRMB_ACISJ
AccessioniPrimary (citable) accession number: A1W7D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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