Reviewed, UniProtKB/Swiss-Prot A1W6H6 (GLYA_ACISJ)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase
      Short name=Serine methylase
      Short name=SHMT
    EC=2.1.2.1

Gene names

Name:	glyA
Ordered Locus Names:	Ajs_1660

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Serine hydroxymethyltransferase HAMAP MF_00051		PRO_1000006211
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1W6H6-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 143BA06E78BBF18A	FASTA	414	45,233
	10 20 30 40 50 60 MYQRNILVEQ TDPEVWAAIQ AEDRRQEEHI ELIASENYAS PAVMAAQGSQ LTNKYAEGYP 70 80 90 100 110 120 GKRYYGGCEN VDVIEQLAID RIKQLFGAEA ANVQPNSGSQ ANQAVLMAFL KPGDTILGMS 130 140 150 160 170 180 LAEGGHLTHG MPLNMSGKWF NVVSYGLNDK EEIDYDALEA KAREHKPKLI IAGASAYALR 190 200 210 220 230 240 IDFERFAKIA KEVGAIFWVD IAHYAGLVVA GEYPNPVPFA DVVTSTTHKS LRGPRGGIIL 250 260 270 280 290 300 MKAEHEKAIN SAIFPGLQGG PLEHVIAAKA VAFKEALSPE FKQYQQQVTK NAKVFAETLI 310 320 330 340 350 360 QRGLRIVSGR TESHVMLVDL RAKGITGKEA EAALGKAHIT INKNAIPNDP EKPMVTSGIR 370 380 390 400 410 VGTPAITTRG FKEEETRLTA NLVADVLDNP HDEANLEAVR AKVHALTSRF PVYR

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000539 Genomic DNA. Translation: ABM41851.1.
RefSeq	YP_985927.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1W6H6.
Genome annotation databases
GeneID	4671096.
GenomeReviews	Gene locus Ajs_1660 in contig CP000539_GR.
KEGG	ajs:Ajs_1660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	WTAIQDE.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA_ACISJ

Accession

Primary (citable) accession number: A1W6H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)