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A1W6H4 (AROC_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Ajs_1658
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Chorismate synthase HAMAP MF_00300
PRO_1000022455

Sequences

Sequence LengthMass (Da)Tools
A1W6H4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 74CA46FA55F805E7

FASTA36638,785
        10         20         30         40         50         60 
MSGNTLGTLF CVTNFGESHG PAIGCVIDGC PPGMELSEAD IQADLDRRRP GTSRHVTQRN 

        70         80         90        100        110        120 
EPDAVEILSG VYEGKTTGTP IALLIRNTDQ RSKDYGNIAQ SFRPGHADYA YWHKYGLRDP 

       130        140        150        160        170        180 
RGGGRSSARL TAPTVAAGAV AKKWLAEKYG TRFRACMTQL GELPIPFESW EHVPHNPFFA 

       190        200        210        220        230        240 
PVADVQAYED YMDALRKSGD SCGARIRVQA TGVPVGLGDP LYDKLDADIA HVMMGLNAVK 

       250        260        270        280        290        300 
GVEIGAGFAS VAQRGTTHGD SLTPTGFASN NAGGVLGGIS TGQDIEVSLA IKPTSSIISP 

       310        320        330        340        350        360 
RESIDIHGQS TEVITKGRHD PCVGIRAAPI AEALLALVIM DHALRHRAQC GDVVQAVAPI 


PAVRLG

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM41849.1.
RefSeqYP_985925.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1W6H4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1W6H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4670993.
GenomeReviewsGene locus Ajs_1658 in contig CP000539_GR.
KEGGajs:Ajs_1658.
PATRIC20688642. VBIAciSp27161_1859.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMASRFTTQR.
PhylomeDBA1W6H4.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycASP232721:AJS_1658-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ACISJ
AccessionPrimary (citable) accession number: A1W6H4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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