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A1W5A4

- TYSY_ACISJ

UniProt

A1W5A4 - TYSY_ACISJ

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Protein
Thymidylate synthase
Gene
thyA, Ajs_1197
Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciASP232721:GHWE-1210-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:Ajs_1197
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000645: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Thymidylate synthaseUniRule annotation
PRO_0000321464Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi232721.Ajs_1197.

Structurei

3D structure databases

ProteinModelPortaliA1W5A4.
SMRiA1W5A4. Positions 9-277.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDEWARDD.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1W5A4-1 [UniParc]FASTAAdd to Basket

« Hide

MTPRPIRHQY EDLMRHVFEH GTAKGDRTGT GTKSVFGHQM RFDLSEGFPL    50
VTTKKVHLKS IILELLWFLR GDSNVRWLQE RGCTIWDEWA RDDGSLGPVY 100
GVQWRSWPTP DGGHIDQIQQ VIDTLKTHPD SRRIIVSAWN VAELDRMALM 150
PCHAFFQFYV APSQVAGEPG KLSCQLYQRS ADIFLGVPFN IASYALLTHM 200
VAQQCDLQVG DFIWTGGDCH IYSNHFEQVR TQLARQPYAY PTLQIKRRPA 250
SIFDYAYEDF EVVGYEHHPA IKAPVAV 277
Length:277
Mass (Da):31,748
Last modified:February 6, 2007 - v1
Checksum:iB3589C202F79D389
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM41429.1.
RefSeqiWP_011804629.1. NC_008782.1.
YP_985505.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM41429; ABM41429; Ajs_1197.
GeneIDi4672547.
KEGGiajs:Ajs_1197.
PATRICi20687712. VBIAciSp27161_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM41429.1 .
RefSeqi WP_011804629.1. NC_008782.1.
YP_985505.1. NC_008782.1.

3D structure databases

ProteinModelPortali A1W5A4.
SMRi A1W5A4. Positions 9-277.
ModBasei Search...

Protein-protein interaction databases

STRINGi 232721.Ajs_1197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM41429 ; ABM41429 ; Ajs_1197 .
GeneIDi 4672547.
KEGGi ajs:Ajs_1197.
PATRICi 20687712. VBIAciSp27161_1402.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DEWARDD.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci ASP232721:GHWE-1210-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS42.

Entry informationi

Entry nameiTYSY_ACISJ
AccessioniPrimary (citable) accession number: A1W5A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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