Reviewed, UniProtKB/Swiss-Prot A1W4I7 (NTPA_ACISJ)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

Ajs_0922

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000068406

Sequences

	Sequence		Length	Mass (Da)
	A1W4I7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 4E0B40E53449795A	FASTA	205	21,952
	10 20 30 40 50 60 MKLVLASNNR GKLAELQAML APLGVQLIPQ AELGVGEAEE PFHTFVENAL AKARFASAHT 70 80 90 100 110 120 GLPALADDAG LCVQAFGGQP GVQTAYYATQ FGYDKGDANN VRALLEQMQG IDDRRAAMVS 130 140 150 160 170 180 TLVAVRSPQD PEPLIAVGRV AGEIARAPRG TGGFGFDPVM VLPAFGKTFA ELPPEVKNAH 190 200 SHRGRSSRQM LELMREHWFA GTSER

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000539 Genomic DNA. Translation: ABM41162.1.
RefSeq	YP_985238.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4671820.
GenomeReviews	Gene locus Ajs_0922 in contig CP000539_GR.
KEGG	ajs:Ajs_0922.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A1W4I7. VYTADWA.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_ACISJ

Accession

Primary (citable) accession number: A1W4I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)