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A1W4H1

- NADK_ACISJ

UniProt

A1W4H1 - NADK_ACISJ

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Protein
NAD kinase
Gene
nadK, Ajs_0904
Organism
Acidovorax sp. (strain JS42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptor By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei184 – 1841NAD By similarity
Binding sitei219 – 2191NAD; via carbonyl oxygen By similarity
Binding sitei253 – 2531NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812NAD By similarity
Nucleotide bindingi154 – 1552NAD By similarity
Nucleotide bindingi195 – 2006NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP232721:GHWE-909-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Ajs_0904
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000645: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298NAD kinaseUniRule annotation
PRO_1000005389Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi232721.Ajs_0904.

Structurei

3D structure databases

ProteinModelPortaliA1W4H1.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A1W4H1-1 [UniParc]FASTAAdd to Basket

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MKPIFRRVAV IGKYPGPGAV SASDSARQII ESIAQFVTQQ DCELTLEAET    50
AAHTGLTQYH TLDVEGIGRQ CDLCLVVGGD GTMLGVGRRL AGYGTPLVGI 100
NQGRLGFITD IPLEGYQDAL TPILHGDYEE DVRPLMQACV MRSGECVFEA 150
LALNDVVVNR GSTSGMVELR VEVDGVFVSN QRADGLIVAS PTGSTAYALS 200
AGGPMLHPSI PGWVLVPIAP HTLSNRPIVL SDATEVAIEV AGGRDISANF 250
DMQSLASLQH GDRILVRRSA HRVCFLHPRG WSYFATLRKK LGWYEGGS 298
Length:298
Mass (Da):31,915
Last modified:February 6, 2007 - v1
Checksum:i2613E7C2AE714468
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM41146.1.
RefSeqiWP_011804348.1. NC_008782.1.
YP_985222.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM41146; ABM41146; Ajs_0904.
GeneIDi4671215.
KEGGiajs:Ajs_0904.
PATRICi20687078. VBIAciSp27161_1093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000539 Genomic DNA. Translation: ABM41146.1 .
RefSeqi WP_011804348.1. NC_008782.1.
YP_985222.1. NC_008782.1.

3D structure databases

ProteinModelPortali A1W4H1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 232721.Ajs_0904.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM41146 ; ABM41146 ; Ajs_0904 .
GeneIDi 4671215.
KEGGi ajs:Ajs_0904.
PATRICi 20687078. VBIAciSp27161_1093.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci ASP232721:GHWE-909-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Acidovorax sp. JS42."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS42.

Entry informationi

Entry nameiNADK_ACISJ
AccessioniPrimary (citable) accession number: A1W4H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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