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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Acidovorax sp. (strain JS42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:Ajs_0893
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000000645 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000105551 – 211Peptidyl-tRNA hydrolaseAdd BLAST211

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi232721.Ajs_0893.

Structurei

3D structure databases

ProteinModelPortaliA1W4G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZPD. Bacteria.
COG0193. LUCA.
HOGENOMiHOG000004796.
KOiK01056.
OMAiRFYKILP.
OrthoDBiPOG093B01PW.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiView protein in InterPro
IPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiView protein in Pfam
PF01195. Pept_tRNA_hydro. 1 hit.
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiView protein in PROSITE
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1W4G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLFVGLGN PGPEYEATRH NAGFWWIDAL ARELKVTLVP ERSYHGLVAR
60 70 80 90 100
ASVAGHSVWL LQPQTFMNLS GKSVAALARF FKIPPEEILV AHDELDIPPG
110 120 130 140 150
QAKLKRGGSH AGHNGLRDIH AQLGTSDYWR LRIGIGHPGV KAEVVNWVLK
160 170 180 190 200
KPAPDQRTLI EDSILHSLKA YPALLAGDMD KATLLVHTTK PPRPKTARPA
210
QAQAAPQAGA D
Length:211
Mass (Da):22,978
Last modified:February 6, 2007 - v1
Checksum:i0CBE354CE20B5BDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000539 Genomic DNA. Translation: ABM41135.1.
RefSeqiWP_011804337.1. NC_008782.1.

Genome annotation databases

EnsemblBacteriaiABM41135; ABM41135; Ajs_0893.
KEGGiajs:Ajs_0893.
PATRICi20687054. VBIAciSp27161_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000539 Genomic DNA. Translation: ABM41135.1.
RefSeqiWP_011804337.1. NC_008782.1.

3D structure databases

ProteinModelPortaliA1W4G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi232721.Ajs_0893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM41135; ABM41135; Ajs_0893.
KEGGiajs:Ajs_0893.
PATRICi20687054. VBIAciSp27161_1082.

Phylogenomic databases

eggNOGiENOG4108ZPD. Bacteria.
COG0193. LUCA.
HOGENOMiHOG000004796.
KOiK01056.
OMAiRFYKILP.
OrthoDBiPOG093B01PW.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiView protein in InterPro
IPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiView protein in Pfam
PF01195. Pept_tRNA_hydro. 1 hit.
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiView protein in PROSITE
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_ACISJ
AccessioniPrimary (citable) accession number: A1W4G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.