A1W3F2 (SYGA_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine--tRNA ligase alpha subunit
EC=6.1.1.14

Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	Ajs_0527

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Glycine--tRNA ligase alpha subunit HAMAP MF_00254		PRO_1000047391

Sequences

	Sequence		Length	Mass (Da)
	A1W3F2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: CDA3608A2706A065	FASTA	317	35,632
	10 20 30 40 50 60 MLTFQQIILK LQSYWADQGC ALLQPYDMEV GAGTSHTATF LRALGPEPWK AAYVQPSRRP 70 80 90 100 110 120 KDGRYGENPN RLQHYYQYQV VLKPAPDNIL ELYLGSLEAL GFDLKKNDIR FVEDDWENPT 130 140 150 160 170 180 LGAWGLGWEV WLNGMEVTQF TYFQQVGGID CKPATGEITY GLERLAMYLQ GVDNVYNLTW 190 200 210 220 230 240 TEGPNGAKLT YGDVYHQNEV EQSTYNFEHS DAEFLFTAFG AHEKQANHLM GEQLALPAYE 250 260 270 280 290 300 QVLKAAHTFN LLDARGAISV TERAAYIGRI RNLARAVAKA YLDSRARLGF PMAPKAHADE 310 VLAELAKAAE QQNKKAA

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000539 Genomic DNA. Translation: ABM40777.1.
RefSeq	YP_984853.1. NC_008782.1.
3D structure databases
ProteinModelPortal	A1W3F2.
SMR	A1W3F2. Positions 2-286.
ModBase	Search...
Protein-protein interaction databases
STRING	A1W3F2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4672912.
GenomeReviews	Gene locus Ajs_0527 in contig CP000539_GR.
KEGG	ajs:Ajs_0527.
PATRIC	20686302. VBIAciSp27161_0708.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0752.
HOGENOM	HBG285316.
OMA	CRRPTDG.
PhylomeDB	A1W3F2.
ProtClustDB	PRK09348.
Enzyme and pathway databases
BioCyc	ASP232721:AJS_0527-MONOMER.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
KO	K01878.
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. GlyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_ACISJ

Accession

Primary (citable) accession number: A1W3F2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program