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A1W309 (GLPK_ACISJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Ajs_0382
OrganismAcidovorax sp. (strain JS42) [Complete proteome] [HAMAP]
Taxonomic identifier232721 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase HAMAP MF_00186
PRO_1000098709

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A1W309 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 80017956B2937BF8

FASTA49852,817
        10         20         30         40         50         60 
MTYLLALDQG TSSSRSIVFD ERGHIVAQAQ LELPQIYPQP GWVEHDPLEI WRTQIATARD 

        70         80         90        100        110        120 
ALAKAGIAAN AVRAVGITNQ RETTVLWNRK TGQPVHHAIV WQDRRAEPAC AQLREQGHAA 

       130        140        150        160        170        180 
TIQAKTGLLI DAYFSGTKLQ WLLDHVPGAR DAAEAGELAF GTVDSWLIWQ LTGGKRHVTD 

       190        200        210        220        230        240 
VSNASRTMLF NVHTNQWDDE LLQLLRIPRA LMPEVLPSAS DFGATDAALL GGPIAIGGVA 

       250        260        270        280        290        300 
GDQQSALFGQ ACFTAGMAKN TYGTGCFMLM HTGSRFQKSE NGLLTTSAAQ AGQSPEYAME 

       310        320        330        340        350        360 
GSVFVGGAVV QWLRDGLRAI SASSEVQALA ESVPDSGGVM MVPAFTGLGA PYWKPDARGT 

       370        380        390        400        410        420 
ITGLTRGTTI AHIARAALES IAYQSAALLA AMSRDAVAAG GAPVSELRVD GGACVNDLLM 

       430        440        450        460        470        480 
QFQADLLGIP VVRPAVVETT ALGAAYLAGL ASGVYASTDE LSALWQAERR FTPTLPRSQA 

       490 
EALMARWEHA VAQAVLPG

« Hide

References

[1]"Complete sequence of chromosome 1 of Acidovorax sp. JS42."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000539 Genomic DNA. Translation: ABM40634.1.
RefSeqYP_984710.1. NC_008782.1.

3D structure databases

ProteinModelPortalA1W309.
SMRA1W309. Positions 3-494.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1W309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4671245.
GenomeReviewsGene locus Ajs_0382 in contig CP000539_GR.
KEGGajs:Ajs_0382.
PATRIC20685994. VBIAciSp27161_0555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMAATYFSGT.
PhylomeDBA1W309.
ProtClustDBCLSK897540.

Enzyme and pathway databases

BioCycASP232721:AJS_0382-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_ACISJ
AccessionPrimary (citable) accession number: A1W309
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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