Reviewed, UniProtKB/Swiss-Prot A1W2Z8 (TRPC_ACISJ)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Ajs_0370

Organism

Acidovorax sp. (strain JS42) [Complete proteome] [HAMAP]

Taxonomic identifier

232721 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000018430

Sequences

	Sequence		Length	Mass (Da)
	A1W2Z8-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: DCA1EFD1BAD1FA4A	FASTA	266	29,106
	10 20 30 40 50 60 MSDILKKICD VKVEEVAAAQ KRVSFTDMRR DAESRVLTRD FVGALRAKID QGQAGVIAEI 70 80 90 100 110 120 KKASPSKGVI REDFIPADIA QSYAEGDGKV GAACLSVLTD RQFFQGQPDY LKQARASCPL 130 140 150 160 170 180 PVLRKDFMID PYQIYESRAF GADCVLLIAA CLEDGLMAEM EQIARSLDMA VLVEVHDGAE 190 200 210 220 230 240 LERALRLQTP LVGINNRNLR TFEVSLQTTL DLKKEVPADR LLVAESGILA PVDVHTLRDA 250 260 GVNAFLVGEA FMRAPDPGRA LAQLFA

References

[1]

"Complete sequence of chromosome 1 of Acidovorax sp. JS42." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000539 Genomic DNA. Translation: ABM40623.1.
RefSeq	YP_984699.1.
3D structure databases
SMR	A1W2Z8. Positions 1-265.
ModBase	Search...
Protein-protein interaction databases
STRING	A1W2Z8.
Genome annotation databases
GeneID	4670926.
GenomeReviews	Gene locus Ajs_0370 in contig CP000539_GR.
KEGG	ajs:Ajs_0370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	PLLCKDF.
PhylomeDB	A1W2Z8.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ACISJ

Accession

Primary (citable) accession number: A1W2Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)