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A1W1X2

- LEU1_CAMJJ

UniProt

A1W1X2 - LEU1_CAMJJ

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Protein

2-isopropylmalate synthase

Gene

leuA

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).UniRule annotation

Catalytic activityi

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

Enzyme and pathway databases

BioCyciCJEJ354242:GC51-1698-MONOMER.
UniPathwayiUPA00048; UER00070.

Names & Taxonomyi

Protein namesi
Recommended name:
2-isopropylmalate synthaseUniRule annotation (EC:2.3.3.13UniRule annotation)
Alternative name(s):
Alpha-IPM synthaseUniRule annotation
Alpha-isopropylmalate synthaseUniRule annotation
Gene namesi
Name:leuAUniRule annotation
Ordered Locus Names:CJJ81176_0017
OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Taxonomic identifieri354242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000646: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5115112-isopropylmalate synthasePRO_1000149163Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi354242.CJJ81176_0017.

Structurei

3D structure databases

ProteinModelPortaliA1W1X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000046859.
KOiK01649.
OMAiEGQNALG.
OrthoDBiEOG6CGCF3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01025. LeuA_type1.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1W1X2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDNKIIIFD TTLRDGEQAL GSSLGINQKL QIALALENLG VDVIEAGFPV
60 70 80 90 100
SSQGDFKAVQ KIASKVKNST ICALSRALDK DIDMAYEALK VAKHFRIHTF
110 120 130 140 150
IATSTLHMQD KLKKDFDEIL SMAKRAIIRA RSYTDDVEFS CEDAGRTPID
160 170 180 190 200
NLCFMVENAI KAGAKTINIP DTVGYTLPSE FANIIKILFN KVPNIDKAII
210 220 230 240 250
SVHCHNDLGV ATGNSLSAIL QGARQIECTI NGLGERAGNC ALEEVVMAIK
260 270 280 290 300
TRKDYLKGFY TDIKCENIFK TSKLVSAITN ESIPSHKAIV GSNAFSHSSG
310 320 330 340 350
IHQDGVLKNR QTYEIISPSA IGIHENRMLM TARSGRAMIK TCLENLGYDE
360 370 380 390 400
NTYNLDDVYE RFLRLADKKG QVYDYDLEAL MFLSYENEEE NEFVIEKLSV
410 420 430 440 450
ISGNIPTACV CMRIKEELKT EACTGNGPVE AVFNCIARIT NLKPALKAYS
460 470 480 490 500
INAKSSGVDA QGQVDVDLEF KGRKFHGKGI STDVIEASAQ AFVSAYNAIY
510
RSLKVEERKM A
Length:511
Mass (Da):56,350
Last modified:February 6, 2007 - v1
Checksum:iD446F96FCB66A1D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000538 Genomic DNA. Translation: EAQ71916.1.
RefSeqiYP_001001363.1. NC_008787.1.

Genome annotation databases

EnsemblBacteriaiEAQ71916; EAQ71916; CJJ81176_0017.
GeneIDi4683377.
KEGGicjj:CJJ81176_0017.
PATRICi20053424. VBICamJej103413_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000538 Genomic DNA. Translation: EAQ71916.1 .
RefSeqi YP_001001363.1. NC_008787.1.

3D structure databases

ProteinModelPortali A1W1X2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 354242.CJJ81176_0017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAQ71916 ; EAQ71916 ; CJJ81176_0017 .
GeneIDi 4683377.
KEGGi cjj:CJJ81176_0017.
PATRICi 20053424. VBICamJej103413_1705.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000046859.
KOi K01649.
OMAi EGQNALG.
OrthoDBi EOG6CGCF3.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00070 .
BioCyci CJEJ354242:GC51-1698-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01025. LeuA_type1.
InterProi IPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view ]
SMARTi SM00917. LeuA_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF110921. SSF110921. 1 hit.
TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fouts D.E., Nelson K.E., Sebastian Y.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 81-176.

Entry informationi

Entry nameiLEU1_CAMJJ
AccessioniPrimary (citable) accession number: A1W1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3