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A1W0R3

- TRMB_CAMJJ

UniProt

A1W0R3 - TRMB_CAMJJ

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation
    Binding sitei148 – 1481S-adenosyl-L-methionineUniRule annotation
    Binding sitei175 – 1751S-adenosyl-L-methionineUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei231 – 2311SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCJEJ354242:GC51-1271-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:CJJ81176_1294
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
    Taxonomic identifieri354242 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000646: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392tRNA (guanine-N(7)-)-methyltransferasePRO_0000288133Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi354242.CJJ81176_1294.

    Structurei

    3D structure databases

    ProteinModelPortaliA1W0R3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000252163.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1W0R3-1 [UniParc]FASTAAdd to Basket

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    MPNFKSKKIK EINLPYSKDD VEFLWLAKND NVSLIYTKVQ EESFFLQIKK    50
    AQNGFVIKGD KHTKPSKIGY LQKALKIFKE GFCEDIINEA FGLKNNALIE 100
    KTPFIVDNFD ELLSKLQGKI YIEIGFGSGR HLLYQAKENP NVLILGVEIY 150
    NPALTQVAKL AKVQNVNNIL LIQSDARLLL SVLKSKSVEK IFLHFPVPWD 200
    KKPHRRVIGK DFCKECARVL TQNGRFELRT DSFEYFNFTL EQFLTFPAPK 250
    FSLRKNENLE ISSKYEDRWK KQEKNIYDLW VWNFNQECKN YELNEFNLSS 300
    VEFSKEDLKK IEQNFKNITI KKDDFFLHFE SIYKQDENLL LKVAFGAFNK 350
    PEHCYLHLDK TIDFVFKEPF KIQENIKAIN ELKEILKVQF KI 392
    Length:392
    Mass (Da):46,215
    Last modified:February 6, 2007 - v1
    Checksum:iCE2BE0CBE8DDD2DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000538 Genomic DNA. Translation: EAQ72816.1.
    RefSeqiYP_001000954.1. NC_008787.1.

    Genome annotation databases

    EnsemblBacteriaiEAQ72816; EAQ72816; CJJ81176_1294.
    GeneIDi4682515.
    KEGGicjj:CJJ81176_1294.
    PATRICi20052565. VBICamJej103413_1294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000538 Genomic DNA. Translation: EAQ72816.1 .
    RefSeqi YP_001000954.1. NC_008787.1.

    3D structure databases

    ProteinModelPortali A1W0R3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 354242.CJJ81176_1294.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAQ72816 ; EAQ72816 ; CJJ81176_1294 .
    GeneIDi 4682515.
    KEGGi cjj:CJJ81176_1294.
    PATRICi 20052565. VBICamJej103413_1294.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000252163.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CJEJ354242:GC51-1271-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fouts D.E., Nelson K.E., Sebastian Y.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 81-176.

    Entry informationi

    Entry nameiTRMB_CAMJJ
    AccessioniPrimary (citable) accession number: A1W0R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3