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A1VYV7

- ALF_CAMJJ

UniProt

A1VYV7 - ALF_CAMJJ

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
Active sitei104 – 1041Proton donorBy similarity
Metal bindingi105 – 1051Zinc 1; catalyticBy similarity
Metal bindingi139 – 1391Zinc 2By similarity
Metal bindingi169 – 1691Zinc 2By similarity
Metal bindingi221 – 2211Zinc 1; catalyticBy similarity
Binding sitei222 – 2221Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi260 – 2601Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCJEJ354242:GC51-598-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fbaA, fda, fdaC
Ordered Locus Names:CJJ81176_0625
OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Taxonomic identifieri354242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000646: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Fructose-bisphosphate aldolasePRO_0000281895Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi354242.CJJ81176_0625.

Structurei

3D structure databases

ProteinModelPortaliA1VYV7.
SMRiA1VYV7. Positions 3-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni261 – 2633Dihydroxyacetone phosphate bindingBy similarity
Regioni282 – 2854Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VYV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVLDIVKAG VISGDELNKV YDYAKAEGFA IPAVNVVGTD SINAVLEAAK
60 70 80 90 100
KVNSPVIIQF SNGGAKFYAG KNCPNGEVLG AISGAKHVHL LAKAYGVPVI
110 120 130 140 150
LHTDHAARKL LPWIDGLIEA NAQYKKTHGQ ALFSSHMLDL SEESLEENLS
160 170 180 190 200
TCEVYLQKLD ALGVALEIEL GCTGGEEDGV DNTGIDNSKL YTQPEDVALA
210 220 230 240 250
YERLGKISDK FSIAASFGNV HGVYKPGNVS LQPEILKNSQ KFVKDKFALN
260 270 280 290 300
SDKPINFVFH GGSGSELKDI KNAVSYGVIK MNIDTDTQWA FWDGVREYEL
310 320 330 340 350
KNRAYLQGQI GNPEGDDKPN KKYYDPRVWL RSGEESMIKR LEIAFEDLNC

INKN
Length:354
Mass (Da):38,716
Last modified:February 6, 2007 - v1
Checksum:i3F42FDE4782192C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201V → I in CAA59176. (PubMed:8525063)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84703 Genomic DNA. Translation: CAA59176.1.
CP000538 Genomic DNA. Translation: EAQ73283.1.
PIRiS52413.
RefSeqiYP_001000298.1. NC_008787.1.

Genome annotation databases

EnsemblBacteriaiEAQ73283; EAQ73283; CJJ81176_0625.
GeneIDi4683407.
KEGGicjj:CJJ81176_0625.
PATRICi20051204. VBICamJej103413_0631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84703 Genomic DNA. Translation: CAA59176.1 .
CP000538 Genomic DNA. Translation: EAQ73283.1 .
PIRi S52413.
RefSeqi YP_001000298.1. NC_008787.1.

3D structure databases

ProteinModelPortali A1VYV7.
SMRi A1VYV7. Positions 3-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 354242.CJJ81176_0625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAQ73283 ; EAQ73283 ; CJJ81176_0625 .
GeneIDi 4683407.
KEGGi cjj:CJJ81176_0625.
PATRICi 20051204. VBICamJej103413_0631.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci CJEJ354242:GC51-598-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and characterization of peb4A encoding an antigenic protein in Campylobacter jejuni."
    Burucoa C., Fremaux C., Pei Z., Tummuru M., Blaser M.J., Cenatiempo Y., Fauchere J.L.
    Res. Microbiol. 146:467-476(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Fouts D.E., Nelson K.E., Sebastian Y.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 81-176.

Entry informationi

Entry nameiALF_CAMJJ
AccessioniPrimary (citable) accession number: A1VYV7
Secondary accession number(s): P53818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3