Reviewed, UniProtKB/Swiss-Prot A1VYR7 (PROA_CAMJJ)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	CJJ81176_0583

Organism

Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) [Complete proteome] [HAMAP]

Taxonomic identifier

354242 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_1000049942

Sequences

	Sequence		Length	Mass (Da)
	A1VYR7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: EB2DA9A1E43DD068	FASTA	410	45,999
	10 20 30 40 50 60 MRNLLENIKK NSQKLLNLTP KDKEKIILKL AQILRENFKI ILEANKKDMA NFTKSGAMKD 70 80 90 100 110 120 RLLLDEKRIL ALCEGLEKIA YIEDPIGKIS KGWKNYAGLS IQKMSIPLGL ICVIYEARPS 130 140 150 160 170 180 LSAEIAALMI KSSNACVFKG GSEAKFTNEA IFTLVNKVLK EFDLQDCFAM FTQRDEILQI 190 200 210 220 230 240 LAFDDLIDVI IPRGSSNMIQ EIANNTKIPL IKQNKGLCHA FVDQSANLDM ALKIILNAKC 250 260 270 280 290 300 QRVSVCNALE TLLIHEKIAK NFISLLIPEF KKFKVKIHAH ENALAYFNNS NLKIFKANEN 310 320 330 340 350 360 TFDTEWLDFA LSVKLVKDCD EAIEHINKHS SLHSETIISN DASNIAKFQR LINSSCIYAN 370 380 390 400 410 ASTRFSDGGE FGFGGEVGIS TSKLHARGPM GIEDICTYKY IINGEGQIRE

References

[1]	Fouts D.E., Nelson K.E., Sebastian Y. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000538 Genomic DNA. Translation: EAQ73086.1.
RefSeq	YP_001000258.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4682276.
GenomeReviews	Gene locus CJJ81176_0583 in contig CP000538_GR.
KEGG	cjj:CJJ81176_0583.
TIGR	CJJ81176_0583.
Phylogenomic databases
OMA	A1VYR7. FDTEWLD.
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_CAMJJ

Accession

Primary (citable) accession number: A1VYR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)