A1VYM4 (PUR7_CAMJJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	CJJ81176_0540

Organism

Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) [Complete proteome] [HAMAP]

Taxonomic identifier

354242 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018683

Sequences

	Sequence		Length	Mass (Da)
	A1VYM4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 5A2A04D0B4215E78	FASTA	236	26,926
	10 20 30 40 50 60 MTKKEMLYEG KGKKLFKTDD ENLLISEFKD DLTAFNAEKR GNESGKGALN CKISTEIFHL 70 80 90 100 110 120 LEKNGIKTHL VETISDTEQV VKKCKIVPIE VIVRNVATGS LTKRLGIKDG TVLPFALVEF 130 140 150 160 170 180 CLKDDALGDP FINDEHCLIL NLVQNEAQIS EIKNMARKIN SILTPFFDNK NLRLIDFKIE 190 200 210 220 230 LGLTKDNELV LADEISPDSC RFWDKFSNEK LDKDRFRQDL GNVKMAYEEV LKRILN

References

[1]	Fouts D.E., Nelson K.E., Sebastian Y. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 81-176.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000538 Genomic DNA. Translation: EAQ73331.1.
RefSeq	YP_001000215.1. NC_008787.1.
3D structure databases
ProteinModelPortal	A1VYM4.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VYM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4683410.
GenomeReviews	Gene locus CJJ81176_0540 in contig CP000538_GR.
KEGG	cjj:CJJ81176_0540.
PATRIC	20051033. VBICamJej103413_0548.
TIGR	CJJ81176_0540.
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG306070.
OMA	YKDDALG.
PhylomeDB	A1VYM4.
ProtClustDB	PRK09362.
Enzyme and pathway databases
BioCyc	CJEJ354242:CJJ81176_0540-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CAMJJ

Accession

Primary (citable) accession number: A1VYM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program