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A1VYL5 (HEMH_CAMJJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CJJ81176_0531
OrganismCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) [Complete proteome] [HAMAP]
Taxonomic identifier354242 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Ferrochelatase HAMAP MF_00323
PRO_1000019288

Sites

Metal binding1851Iron By similarity
Metal binding2621Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A1VYL5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 24EF370F22A4E4E2

FASTA30935,767
        10         20         30         40         50         60 
MKLVLFLNMG GATNLQDCEV FLKNMFNDPY ILGIKNRFLR KFVAWIITKA RVKAMQENYK 

        70         80         90        100        110        120 
KMGGKSPLNE LTQSLCNKLN LKQDEFKFDF VNLYVPPFAT EILQKYTLNE SDEIILFPLY 

       130        140        150        160        170        180 
PHHSCTTVTS SLEVLQNEIS KQKIQAKVKT IDIFYKNELY NEMIVSHILD KKSKFDAKIL 

       190        200        210        220        230        240 
IFSAHSLPQS IIDKGDLYEK HVNDHVEILK EKLKDHFDEF ILAYQSKLGP VKWLEPNTSD 

       250        260        270        280        290        300 
VLANLNDKAL IYPISFCIDC SETIFELGME YKHLAKCDYD LISCPNDSDE FMEFILNSIN 


SPLARKTSC

« Hide

References

[1]Fouts D.E., Nelson K.E., Sebastian Y.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 81-176.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000538 Genomic DNA. Translation: EAQ73002.1.
RefSeqYP_001000206.1. NC_008787.1.

3D structure databases

ProteinModelPortalA1VYL5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1VYL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4682394.
GenomeReviewsGene locus CJJ81176_0531 in contig CP000538_GR.
KEGGcjj:CJJ81176_0531.
PATRIC20051015. VBICamJej103413_0539.
TIGRCJJ81176_0531.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMACSETIFE.
PhylomeDBA1VYL5.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCJEJ354242:CJJ81176_0531-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CAMJJ
AccessionPrimary (citable) accession number: A1VYL5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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