A1VY81 (LSPA_CAMJJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein signal peptidase
EC=3.4.23.36

Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name=SPase II

Gene names

Name:	lspA
Ordered Locus Names:	CJJ81176_0384

Organism

Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) [Complete proteome] [HAMAP]

Taxonomic identifier

354242 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161
Catalytic activity	Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161
Pathway	Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.
Sequence similarities	Belongs to the peptidase A8 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Aspartyl protease Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Lipoprotein signal peptidase HAMAP MF_00161		PRO_1000097244
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
Sites
	Active site	104	1	By similarity
	Active site	130	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1VY81 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A9D19E5BC5DF780D	FASTA	156	18,307
	10 20 30 40 50 60 MAKTFKFIFY FWGAFVLVFA LDQWVKSLTL AGLRWQSEYL DLTYALNTGV AFSMLSFLEH 70 80 90 100 110 120 NLKYLHLALI VVLFIYLFWQ KTLLKTHSIA FGMMLGAGVS NLLDRFIHGG VVDMFFWHKW 130 140 150 FNFAIFNVAD VMINISVALI LIQEIFKKRK KDDRMD

References

[1]	Fouts D.E., Nelson K.E., Sebastian Y. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 81-176.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000538 Genomic DNA. Translation: EAQ73308.1.
RefSeq	YP_001000072.1. NC_008787.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1VY81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4682903.
GenomeReviews	Gene locus CJJ81176_0384 in contig CP000538_GR.
KEGG	cjj:CJJ81176_0384.
PATRIC	20050725. VBICamJej103413_0405.
TIGR	CJJ81176_0384.
Phylogenomic databases
eggNOG	COG0597.
HOGENOM	HBG724422.
OMA	GVAFSMF.
ProtClustDB	PRK00376.
Enzyme and pathway databases
BioCyc	CJEJ354242:CJJ81176_0384-MONOMER.
Family and domain databases
HAMAP	MF_00161. LspA. [Tree]
InterPro	IPR001872. Peptidase_A8. [Graphical view]
KO	K03101.
Pfam	PF01252. Peptidase_A8. 1 hit. [Graphical view]
PRINTS	PR00781. LIPOSIGPTASE.
TIGRFAMs	TIGR00077. LspA. 1 hit.
PROSITE	PS00855. SPASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LSPA_CAMJJ

Accession

Primary (citable) accession number: A1VY81

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program