A1VXS2 (GCH1_CAMJJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	CJJ81176_0225

Organism

Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) [Complete proteome] [HAMAP]

Taxonomic identifier

354242 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000043673
Sites
	Metal binding	75	1	Zinc By similarity
	Metal binding	78	1	Zinc By similarity
	Metal binding	146	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1VXS2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 24A97AEB292EB421	FASTA	190	21,830
	10 20 30 40 50 60 MQKKFEDCVK TMLEIIGENP NREGLIKTPN RVFKTYEFLT SGYTQNVKEI LNDALFESSN 70 80 90 100 110 120 NEMVLVRDIE FYSLCEHHLL PFFGRAHVAY IPNKKVVGLS KIPRLVEVFA RRLQIQEQLT 130 140 150 160 170 180 EQIAQALMEN VDAKGVGVVI EARHMCVEMR GVQKANSTTT TSALRGIFLK NEKTREEFFS 190 LINSAKQVRF

References

[1]	Fouts D.E., Nelson K.E., Sebastian Y. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 81-176.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000538 Genomic DNA. Translation: EAQ73420.1.
RefSeq	YP_999913.1. NC_008787.1.
3D structure databases
ProteinModelPortal	A1VXS2.
SMR	A1VXS2. Positions 2-183.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VXS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4683363.
GenomeReviews	Gene locus CJJ81176_0225 in contig CP000538_GR.
KEGG	cjj:CJJ81176_0225.
PATRIC	20050406. VBICamJej103413_0246.
TIGR	CJJ81176_0225.
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	LPFMGRA.
PhylomeDB	A1VXS2.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	CJEJ354242:CJJ81176_0225-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_CAMJJ

Accession

Primary (citable) accession number: A1VXS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program