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A1VXA2

- A1VXA2_CAMJJ

UniProt

A1VXA2 - A1VXA2_CAMJJ

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Protein

Adenylosuccinate lyase

Gene

purB-1

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCJEJ354242:GC51-24-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purB-1Imported
Ordered Locus Names:CJJ81176_0050Imported
OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)Imported
Taxonomic identifieri354242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000646: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi354242.CJJ81176_0050.

Structurei

3D structure databases

ProteinModelPortaliA1VXA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000033912.
KOiK01756.
OMAiRNMGSTF.
OrthoDBiEOG686NDB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VXA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVERYSREIM AKKWDMQAKY DAWLKVELAA VKAWNKLGLI DDTDCEKILK
60 70 80 90 100
NAKFDIARID EIEKTTKHDV IAFLTSVSES LGEESRFVHY AMTSSDCIDT
110 120 130 140 150
AVALQIKESL ELILEDVSLL LEAIKKRALE HKNTLMVGRS HGIHGEPITF
160 170 180 190 200
GLVLAIWYDE ISHAKELLEH AKEVISYGKI SGAMGNFAHA PLEFEEEVCK
210 220 230 240 250
NLGLKAAPVS NQVIQRDRYA QVISAIAILA SSCEQIAVAI RHFQRTEVYE
260 270 280 290 300
AEEYFSVGQK GSSAMPHKRN PVLSENITGL CRVLRSFVTP ALENVALWHE
310 320 330 340 350
RDISHSSVER FILPDAFITA DFMLMRLTNL IDKLLVYPEN MMKNLNLTGG
360 370 380 390 400
LVFSGRVLLE LPFKGISREE AYKIVQRNAM KVWADLQNGK AAINEKNESL
410 420 430 440
FLLALLSDED LRKSLSEEDV RKCFDYNYYT KNVDAIFKRT FK
Length:442
Mass (Da):50,201
Last modified:February 6, 2007 - v1
Checksum:iBB6FDFEBE163D70F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000538 Genomic DNA. Translation: EAQ71984.1.
RefSeqiYP_999743.1. NC_008787.1.

Genome annotation databases

EnsemblBacteriaiEAQ71984; EAQ71984; CJJ81176_0050.
GeneIDi4682961.
KEGGicjj:CJJ81176_0050.
PATRICi20050048. VBICamJej103413_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000538 Genomic DNA. Translation: EAQ71984.1 .
RefSeqi YP_999743.1. NC_008787.1.

3D structure databases

ProteinModelPortali A1VXA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 354242.CJJ81176_0050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAQ71984 ; EAQ71984 ; CJJ81176_0050 .
GeneIDi 4682961.
KEGGi cjj:CJJ81176_0050.
PATRICi 20050048. VBICamJej103413_0074.

Phylogenomic databases

eggNOGi COG0015.
HOGENOMi HOG000033912.
KOi K01756.
OMAi RNMGSTF.
OrthoDBi EOG686NDB.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00132 .
UPA00075 ; UER00336 .
BioCyci CJEJ354242:GC51-24-MONOMER.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
InterProi IPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SMARTi SM00998. ADSL_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00928. purB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fouts D.E., Nelson K.E., Sebastian Y.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 81-176Imported.

Entry informationi

Entry nameiA1VXA2_CAMJJ
AccessioniPrimary (citable) accession number: A1VXA2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3