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A1VUV2

- ACDH_POLNA

UniProt

A1VUV2 - ACDH_POLNA

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Protein

Acetaldehyde dehydrogenase

Gene

Pnap_4143

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
Binding sitei273 – 2731NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1709NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-4198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Pnap_4143
Encoded oniPlasmid pPNAP010 Publication
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Plasmid pPNAP01

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Acetaldehyde dehydrogenasePRO_0000387703Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi365044.Pnap_4143.

Structurei

3D structure databases

ProteinModelPortaliA1VUV2.
SMRiA1VUV2. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiVEPPMIM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VUV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKIKCALI GPGNIGTDLL AKLQRSAVLE PVWMVGIDPE SDGLKRAREM
60 70 80 90 100
GIKTTADGVD GLIPHMQADG VQIVFDATSA YVHAENSRKV NAQGALMIDL
110 120 130 140 150
TPAAIGPFCV PPVNLIEHVG KGEMNVNMVT CGGQATIPMV AAVSRVQPVA
160 170 180 190 200
YGEIIATVSS KSAGPGTRKN IDEFTRTTAS AVEKVGGAKK GKAIIILNPA
210 220 230 240 250
EPPLIMRDTV HCLLESEPDQ AKITESIHAM IQEVQKYVPG YKLVNGPVFD
260 270 280 290 300
GKRVSVFLEV EGLGDYLPKY AGNLDIMTAA AARTAEMFAE EILAGRLTLK

PVHA
Length:304
Mass (Da):32,279
Last modified:February 6, 2007 - v1
Checksum:i96D94FB2297DECBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000530 Genomic DNA. Translation: ABM39430.1.
RefSeqiWP_011797809.1. NC_008757.1.
YP_973172.1. NC_008757.1.

Genome annotation databases

EnsemblBacteriaiABM39430; ABM39430; Pnap_4143.
GeneIDi4685445.
KEGGipna:Pnap_4143.
PATRICi22942883. VBIPolNap76733_0019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000530 Genomic DNA. Translation: ABM39430.1 .
RefSeqi WP_011797809.1. NC_008757.1.
YP_973172.1. NC_008757.1.

3D structure databases

ProteinModelPortali A1VUV2.
SMRi A1VUV2. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_4143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM39430 ; ABM39430 ; Pnap_4143 .
GeneIDi 4685445.
KEGGi pna:Pnap_4143.
PATRICi 22942883. VBIPolNap76733_0019.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi VEPPMIM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci PNAP365044:GJ8X-4198-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of plasmid pPNAP01 of Polaromonas naphthalenivorans CJ2."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Madsen E.L., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiACDH_POLNA
AccessioniPrimary (citable) accession number: A1VUV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3