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A1VUV2

- ACDH_POLNA

UniProt

A1VUV2 - ACDH_POLNA

Protein

Acetaldehyde dehydrogenase

Gene

Pnap_4143

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
    Binding sitei273 – 2731NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi162 – 1709NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-4198-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Pnap_4143
    Encoded oniPlasmid pPNAP010 Publication
    OrganismiPolaromonas naphthalenivorans (strain CJ2)
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000000644: Plasmid pPNAP01

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Acetaldehyde dehydrogenasePRO_0000387703Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi365044.Pnap_4143.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VUV2.
    SMRiA1VUV2. Positions 1-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiVEPPMIM.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VUV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKIKCALI GPGNIGTDLL AKLQRSAVLE PVWMVGIDPE SDGLKRAREM    50
    GIKTTADGVD GLIPHMQADG VQIVFDATSA YVHAENSRKV NAQGALMIDL 100
    TPAAIGPFCV PPVNLIEHVG KGEMNVNMVT CGGQATIPMV AAVSRVQPVA 150
    YGEIIATVSS KSAGPGTRKN IDEFTRTTAS AVEKVGGAKK GKAIIILNPA 200
    EPPLIMRDTV HCLLESEPDQ AKITESIHAM IQEVQKYVPG YKLVNGPVFD 250
    GKRVSVFLEV EGLGDYLPKY AGNLDIMTAA AARTAEMFAE EILAGRLTLK 300
    PVHA 304
    Length:304
    Mass (Da):32,279
    Last modified:February 6, 2007 - v1
    Checksum:i96D94FB2297DECBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000530 Genomic DNA. Translation: ABM39430.1.
    RefSeqiYP_973172.1. NC_008757.1.

    Genome annotation databases

    EnsemblBacteriaiABM39430; ABM39430; Pnap_4143.
    GeneIDi4685445.
    KEGGipna:Pnap_4143.
    PATRICi22942883. VBIPolNap76733_0019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000530 Genomic DNA. Translation: ABM39430.1 .
    RefSeqi YP_973172.1. NC_008757.1.

    3D structure databases

    ProteinModelPortali A1VUV2.
    SMRi A1VUV2. Positions 1-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_4143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM39430 ; ABM39430 ; Pnap_4143 .
    GeneIDi 4685445.
    KEGGi pna:Pnap_4143.
    PATRICi 22942883. VBIPolNap76733_0019.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi VEPPMIM.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci PNAP365044:GJ8X-4198-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of plasmid pPNAP01 of Polaromonas naphthalenivorans CJ2."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Madsen E.L., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2.

    Entry informationi

    Entry nameiACDH_POLNA
    AccessioniPrimary (citable) accession number: A1VUV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3