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A1VTV4

- SYL_POLNA

UniProt

A1VTV4 - SYL_POLNA

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Protein
Leucine--tRNA ligase
Gene
leuS, Pnap_3786
Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei643 – 6431ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pnap_3786
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 888888Leucine--tRNA ligaseUniRule annotation
PRO_1000009390Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi365044.Pnap_3786.

Structurei

3D structure databases

ProteinModelPortaliA1VTV4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi640 – 6445"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VTV4-1 [UniParc]FASTAAdd to Basket

« Hide

MQDKYNHLDV ERSAQTHWNA ADAYRVTEDA SRKKYYACSM LPYPSGKLHM    50
GHVRNYTIND MLSRYLRMKG YNVLMPMGWD AFGLPAENAA LKNGVPPAQW 100
TYDNIAYMKK QMQAMGLAVD WSREIATCDP SYYKWNQWLF LKMLEKGIAY 150
RKTQVVNWDP VDQTVLANEQ VIDGKGWRTG ATVEKREIPG YYLKITDYAE 200
ELLGSVQHKL PGWPERVKLM QENWIGKSEG VRFAFLHDIK DASGALIGDG 250
QMYVFTTRAD TIMGVTFCAV APEHPLAVHA AASNPALAAF VEECKSGGTT 300
EAELATQEKK GQPTGLFVTH PLTGDKVEVW VGNYVLMSYG DGAVMGVPAH 350
DERDFEFAKK YGLPIKQVTD VKGQAYSLDA WADWYGDKQH GIAINSGKYD 400
GLAFKAAVDA IAADLAALGL GEKKTTWRLR DWGVSRQRYW GTPIPIIHCD 450
EHGAVPVPEK DLPVVLPMDC IPDGSGNPLH KHEGFHAGVV CPVCGKPARR 500
ETDTMDTFVD SSWYFMRYCD PKNSEAMVAG GADYWMPMDQ YIGGIEHAIL 550
HLLYARFWTK VMRDLGLVKV DEPFTKLLTQ GMVLNHIYSR RTDKGGKEYF 600
WPHDVEHVLD DTGKIAGARL KNAVGDLPVG TAIDYEGVGT MSKSKNNGVD 650
PQDIIEKYGA DTARLYTMFT APPEATLEWN DAGVEGSYRF LRRVWNFGVK 700
LNAMNSGANG ADAACAKGLF DKETKALRLE VHTLLKQVDY DYQRMQYNTV 750
VSGGMKLLNA LEDFKGEISA ASLAALREGF SVLLRCLYPA APHLTHALWS 800
ELGYAAEAGD LLDTPWPEVD ASALQQDEIE LMLQINGKLR GSVTVPAGAD 850
KAVIEAAALA SEAFVKQAAG APAKKVIVVP GRLVNIVV 888
Length:888
Mass (Da):98,298
Last modified:February 6, 2007 - v1
Checksum:iFB63D4C5260D8D59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM39082.1.
RefSeqiYP_984003.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM39082; ABM39082; Pnap_3786.
GeneIDi4686290.
KEGGipna:Pnap_3786.
PATRICi22952337. VBIPolNap76733_4684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM39082.1 .
RefSeqi YP_984003.1. NC_008781.1.

3D structure databases

ProteinModelPortali A1VTV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_3786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM39082 ; ABM39082 ; Pnap_3786 .
GeneIDi 4686290.
KEGGi pna:Pnap_3786.
PATRICi 22952337. VBIPolNap76733_4684.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PNAP365044:GJ8X-3841-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiSYL_POLNA
AccessioniPrimary (citable) accession number: A1VTV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi