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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei643ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pnap_3786
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
Proteomesi
  • UP000000644 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093901 – 888Leucine--tRNA ligaseAdd BLAST888

Proteomic databases

PRIDEiA1VTV4

Interactioni

Protein-protein interaction databases

STRINGi365044.Pnap_3786

Structurei

3D structure databases

ProteinModelPortaliA1VTV4
SMRiA1VTV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi640 – 644"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1VTV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKYNHLDV ERSAQTHWNA ADAYRVTEDA SRKKYYACSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND MLSRYLRMKG YNVLMPMGWD AFGLPAENAA LKNGVPPAQW
110 120 130 140 150
TYDNIAYMKK QMQAMGLAVD WSREIATCDP SYYKWNQWLF LKMLEKGIAY
160 170 180 190 200
RKTQVVNWDP VDQTVLANEQ VIDGKGWRTG ATVEKREIPG YYLKITDYAE
210 220 230 240 250
ELLGSVQHKL PGWPERVKLM QENWIGKSEG VRFAFLHDIK DASGALIGDG
260 270 280 290 300
QMYVFTTRAD TIMGVTFCAV APEHPLAVHA AASNPALAAF VEECKSGGTT
310 320 330 340 350
EAELATQEKK GQPTGLFVTH PLTGDKVEVW VGNYVLMSYG DGAVMGVPAH
360 370 380 390 400
DERDFEFAKK YGLPIKQVTD VKGQAYSLDA WADWYGDKQH GIAINSGKYD
410 420 430 440 450
GLAFKAAVDA IAADLAALGL GEKKTTWRLR DWGVSRQRYW GTPIPIIHCD
460 470 480 490 500
EHGAVPVPEK DLPVVLPMDC IPDGSGNPLH KHEGFHAGVV CPVCGKPARR
510 520 530 540 550
ETDTMDTFVD SSWYFMRYCD PKNSEAMVAG GADYWMPMDQ YIGGIEHAIL
560 570 580 590 600
HLLYARFWTK VMRDLGLVKV DEPFTKLLTQ GMVLNHIYSR RTDKGGKEYF
610 620 630 640 650
WPHDVEHVLD DTGKIAGARL KNAVGDLPVG TAIDYEGVGT MSKSKNNGVD
660 670 680 690 700
PQDIIEKYGA DTARLYTMFT APPEATLEWN DAGVEGSYRF LRRVWNFGVK
710 720 730 740 750
LNAMNSGANG ADAACAKGLF DKETKALRLE VHTLLKQVDY DYQRMQYNTV
760 770 780 790 800
VSGGMKLLNA LEDFKGEISA ASLAALREGF SVLLRCLYPA APHLTHALWS
810 820 830 840 850
ELGYAAEAGD LLDTPWPEVD ASALQQDEIE LMLQINGKLR GSVTVPAGAD
860 870 880
KAVIEAAALA SEAFVKQAAG APAKKVIVVP GRLVNIVV
Length:888
Mass (Da):98,298
Last modified:February 6, 2007 - v1
Checksum:iFB63D4C5260D8D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA Translation: ABM39082.1
RefSeqiWP_011803148.1, NC_008781.1

Genome annotation databases

EnsemblBacteriaiABM39082; ABM39082; Pnap_3786
KEGGipna:Pnap_3786

Similar proteinsi

Entry informationi

Entry nameiSYL_POLNA
AccessioniPrimary (citable) accession number: A1VTV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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