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A1VTJ8

- A1VTJ8_POLNA

UniProt

A1VTJ8 - A1VTJ8_POLNA

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Protein
Submitted name: Isocitrate dehydrogenase, NADP-dependent
Gene
Pnap_3680
Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3735-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Pnap_3680Imported
OrganismiPolaromonas naphthalenivorans (strain CJ2)Imported
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi365044.Pnap_3680.

Structurei

3D structure databases

ProteinModelPortaliA1VTJ8.
SMRiA1VTJ8. Positions 7-741.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VTJ8-1 [UniParc]FASTAAdd to Basket

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MTAGKSKIIY TLTDEAPLLA TWSFLPVVRA FTAPAGIEVA ESDISVAARV    50
LAEFPEFLSD AQKVPNTLAE LGRLTQDPDT NIIKLPNISA SQGQLVSAIK 100
ELQSKGFNLP DYPESPKSDE DKAIRARYAR CIGSSVNPVL REGNSDRRAP 150
LAVKNYARKN PHSMADWSQA SRSHVSHMHH GDFYHGEKSM TLDKARDVKM 200
ELITKSGKTI VLKPLTKLLD REVIDSMFMS KKELLDFYEQ EIDDAYKTGV 250
MFSLHVKATM MKVSHPIVFG HCVKIFYKDA FEKHAKLFDE LGVNVNNGMA 300
NLYDKISTLP QSTQDEIKRD LHACHEHRPE LAMVDSAKGI TNFHSPNDVI 350
VDASMPAMIR NGGKMWGADG RLKDVKAVMP ESTFARIYQE IINFCKWHGA 400
FDPKTMGTVP NVGLMAQQAE EYGSHDKTFE ISEDGVANIT DVATGEVLLS 450
QNVEAGDIWR MCQCKDAAIR DWVKLAVNRA RNSGMPVVFW LDAYRPHEAQ 500
LITKVKMYLH EHNTSGLDIQ IMSQVRAMRY TLERVVRGQD TISATGNILR 550
DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN 600
HLRWDSLGEF LALAVSLEDL GIKTGNDQAK LLAKTLDAAT GKLLDNNKGP 650
KTRTGELDNR GSHFYLAMYW AQALAEQTQD AALQARFAPL AKSLAENEAQ 700
IVAEFKEVQG KPVDIGGYYL LDAEKVKAVM RPSATFNAVL SAAQA 745
Length:745
Mass (Da):82,437
Last modified:February 6, 2007 - v1
Checksum:iFA1F3F6567DD1086
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38976.1.
RefSeqiWP_011803042.1. NC_008781.1.
YP_983897.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM38976; ABM38976; Pnap_3680.
GeneIDi4689721.
KEGGipna:Pnap_3680.
PATRICi22952113. VBIPolNap76733_4572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38976.1 .
RefSeqi WP_011803042.1. NC_008781.1.
YP_983897.1. NC_008781.1.

3D structure databases

ProteinModelPortali A1VTJ8.
SMRi A1VTJ8. Positions 7-741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_3680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM38976 ; ABM38976 ; Pnap_3680 .
GeneIDi 4689721.
KEGGi pna:Pnap_3680.
PATRICi 22952113. VBIPolNap76733_4572.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci PNAP365044:GJ8X-3735-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiA1VTJ8_POLNA
AccessioniPrimary (citable) accession number: A1VTJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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