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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Pnap_3680

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3735-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Pnap_3680Imported
OrganismiPolaromonas naphthalenivorans (strain CJ2)Imported
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi365044.Pnap_3680.

Structurei

3D structure databases

ProteinModelPortaliA1VTJ8.
SMRiA1VTJ8. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VTJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAGKSKIIY TLTDEAPLLA TWSFLPVVRA FTAPAGIEVA ESDISVAARV
60 70 80 90 100
LAEFPEFLSD AQKVPNTLAE LGRLTQDPDT NIIKLPNISA SQGQLVSAIK
110 120 130 140 150
ELQSKGFNLP DYPESPKSDE DKAIRARYAR CIGSSVNPVL REGNSDRRAP
160 170 180 190 200
LAVKNYARKN PHSMADWSQA SRSHVSHMHH GDFYHGEKSM TLDKARDVKM
210 220 230 240 250
ELITKSGKTI VLKPLTKLLD REVIDSMFMS KKELLDFYEQ EIDDAYKTGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HCVKIFYKDA FEKHAKLFDE LGVNVNNGMA
310 320 330 340 350
NLYDKISTLP QSTQDEIKRD LHACHEHRPE LAMVDSAKGI TNFHSPNDVI
360 370 380 390 400
VDASMPAMIR NGGKMWGADG RLKDVKAVMP ESTFARIYQE IINFCKWHGA
410 420 430 440 450
FDPKTMGTVP NVGLMAQQAE EYGSHDKTFE ISEDGVANIT DVATGEVLLS
460 470 480 490 500
QNVEAGDIWR MCQCKDAAIR DWVKLAVNRA RNSGMPVVFW LDAYRPHEAQ
510 520 530 540 550
LITKVKMYLH EHNTSGLDIQ IMSQVRAMRY TLERVVRGQD TISATGNILR
560 570 580 590 600
DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN
610 620 630 640 650
HLRWDSLGEF LALAVSLEDL GIKTGNDQAK LLAKTLDAAT GKLLDNNKGP
660 670 680 690 700
KTRTGELDNR GSHFYLAMYW AQALAEQTQD AALQARFAPL AKSLAENEAQ
710 720 730 740
IVAEFKEVQG KPVDIGGYYL LDAEKVKAVM RPSATFNAVL SAAQA
Length:745
Mass (Da):82,437
Last modified:February 6, 2007 - v1
Checksum:iFA1F3F6567DD1086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM38976.1.
RefSeqiWP_011803042.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM38976; ABM38976; Pnap_3680.
KEGGipna:Pnap_3680.
PATRICi22952113. VBIPolNap76733_4572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM38976.1.
RefSeqiWP_011803042.1. NC_008781.1.

3D structure databases

ProteinModelPortaliA1VTJ8.
SMRiA1VTJ8. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi365044.Pnap_3680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM38976; ABM38976; Pnap_3680.
KEGGipna:Pnap_3680.
PATRICi22952113. VBIPolNap76733_4572.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3735-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2Imported.

Entry informationi

Entry nameiA1VTJ8_POLNA
AccessioniPrimary (citable) accession number: A1VTJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.