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A1VTJ8

- A1VTJ8_POLNA

UniProt

A1VTJ8 - A1VTJ8_POLNA

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Pnap_3680

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471Substrate
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-3735-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Pnap_3680Imported
    OrganismiPolaromonas naphthalenivorans (strain CJ2)Imported
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000000644: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi365044.Pnap_3680.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VTJ8.
    SMRiA1VTJ8. Positions 7-741.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate binding

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiSIVKLMQ.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VTJ8-1 [UniParc]FASTAAdd to Basket

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    MTAGKSKIIY TLTDEAPLLA TWSFLPVVRA FTAPAGIEVA ESDISVAARV    50
    LAEFPEFLSD AQKVPNTLAE LGRLTQDPDT NIIKLPNISA SQGQLVSAIK 100
    ELQSKGFNLP DYPESPKSDE DKAIRARYAR CIGSSVNPVL REGNSDRRAP 150
    LAVKNYARKN PHSMADWSQA SRSHVSHMHH GDFYHGEKSM TLDKARDVKM 200
    ELITKSGKTI VLKPLTKLLD REVIDSMFMS KKELLDFYEQ EIDDAYKTGV 250
    MFSLHVKATM MKVSHPIVFG HCVKIFYKDA FEKHAKLFDE LGVNVNNGMA 300
    NLYDKISTLP QSTQDEIKRD LHACHEHRPE LAMVDSAKGI TNFHSPNDVI 350
    VDASMPAMIR NGGKMWGADG RLKDVKAVMP ESTFARIYQE IINFCKWHGA 400
    FDPKTMGTVP NVGLMAQQAE EYGSHDKTFE ISEDGVANIT DVATGEVLLS 450
    QNVEAGDIWR MCQCKDAAIR DWVKLAVNRA RNSGMPVVFW LDAYRPHEAQ 500
    LITKVKMYLH EHNTSGLDIQ IMSQVRAMRY TLERVVRGQD TISATGNILR 550
    DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN 600
    HLRWDSLGEF LALAVSLEDL GIKTGNDQAK LLAKTLDAAT GKLLDNNKGP 650
    KTRTGELDNR GSHFYLAMYW AQALAEQTQD AALQARFAPL AKSLAENEAQ 700
    IVAEFKEVQG KPVDIGGYYL LDAEKVKAVM RPSATFNAVL SAAQA 745
    Length:745
    Mass (Da):82,437
    Last modified:February 6, 2007 - v1
    Checksum:iFA1F3F6567DD1086
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38976.1.
    RefSeqiWP_011803042.1. NC_008781.1.
    YP_983897.1. NC_008781.1.

    Genome annotation databases

    EnsemblBacteriaiABM38976; ABM38976; Pnap_3680.
    GeneIDi4689721.
    KEGGipna:Pnap_3680.
    PATRICi22952113. VBIPolNap76733_4572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38976.1 .
    RefSeqi WP_011803042.1. NC_008781.1.
    YP_983897.1. NC_008781.1.

    3D structure databases

    ProteinModelPortali A1VTJ8.
    SMRi A1VTJ8. Positions 7-741.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_3680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM38976 ; ABM38976 ; Pnap_3680 .
    GeneIDi 4689721.
    KEGGi pna:Pnap_3680.
    PATRICi 22952113. VBIPolNap76733_4572.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi SIVKLMQ.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci PNAP365044:GJ8X-3735-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2Imported.

    Entry informationi

    Entry nameiA1VTJ8_POLNA
    AccessioniPrimary (citable) accession number: A1VTJ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3