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A1VSM6

- GSA_POLNA

UniProt

A1VSM6 - GSA_POLNA

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3405-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Pnap_3357
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei282 – 2821N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi365044.Pnap_3357.

Structurei

3D structure databases

ProteinModelPortaliA1VSM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTVIGHAN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VSM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQPNTKPVA PATSRNAALF ERAQKLIPGG VNSPVRAFKA VGGTPRFIQR
60 70 80 90 100
AQGAYFWDAD GQRYIDYIGS WGPMILGHGH PAVVEAVQKA VLEGFSYGAP
110 120 130 140 150
TEREVELAEE IVKLVPSIEM VRLVSSGTEA TMSVIRLARG ATGRSKIIKF
160 170 180 190 200
EGCYHGHSDA LLVKAGSGLA TFGSPTSAGV PPEVVQHTLV LEYNHIAQLE
210 220 230 240 250
EAFSLHGRDI ACLMIEPIAG NMNFVRASVP FIKRCRELCT QYDALLVFDE
260 270 280 290 300
VMTGFRVALG GAQSVYAQSI PGFKPDITAL GKVIGGGMPM AAFGGTRAVM
310 320 330 340 350
EHLAPLGGVY QAGTLSGNPV ATACGLATLR EIQKPGFYDA LGARTRSLVE
360 370 380 390 400
GLTHAANQAG VPFCGDSEGG MFGFFLLGTL PQNYPQVMKT DSPTFNRFFH
410 420 430 440
AMLDSGVYYA PALYEAGFVS AAHTAEDIEA TVEAATRFFA GR
Length:442
Mass (Da):47,088
Last modified:February 6, 2007 - v1
Checksum:i4B559C85BDB16F36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM38654.1.
RefSeqiWP_011802725.1. NC_008781.1.
YP_983575.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM38654; ABM38654; Pnap_3357.
GeneIDi4689643.
KEGGipna:Pnap_3357.
PATRICi22951429. VBIPolNap76733_4236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM38654.1 .
RefSeqi WP_011802725.1. NC_008781.1.
YP_983575.1. NC_008781.1.

3D structure databases

ProteinModelPortali A1VSM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_3357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM38654 ; ABM38654 ; Pnap_3357 .
GeneIDi 4689643.
KEGGi pna:Pnap_3357.
PATRICi 22951429. VBIPolNap76733_4236.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi TVIGHAN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci PNAP365044:GJ8X-3405-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiGSA_POLNA
AccessioniPrimary (citable) accession number: A1VSM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3