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A1VSM6

- GSA_POLNA

UniProt

A1VSM6 - GSA_POLNA

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-3405-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Pnap_3357
    OrganismiPolaromonas naphthalenivorans (strain CJ2)
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000000644: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382355Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei282 – 2821N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi365044.Pnap_3357.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VSM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiTVIGHAN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VSM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPNTKPVA PATSRNAALF ERAQKLIPGG VNSPVRAFKA VGGTPRFIQR    50
    AQGAYFWDAD GQRYIDYIGS WGPMILGHGH PAVVEAVQKA VLEGFSYGAP 100
    TEREVELAEE IVKLVPSIEM VRLVSSGTEA TMSVIRLARG ATGRSKIIKF 150
    EGCYHGHSDA LLVKAGSGLA TFGSPTSAGV PPEVVQHTLV LEYNHIAQLE 200
    EAFSLHGRDI ACLMIEPIAG NMNFVRASVP FIKRCRELCT QYDALLVFDE 250
    VMTGFRVALG GAQSVYAQSI PGFKPDITAL GKVIGGGMPM AAFGGTRAVM 300
    EHLAPLGGVY QAGTLSGNPV ATACGLATLR EIQKPGFYDA LGARTRSLVE 350
    GLTHAANQAG VPFCGDSEGG MFGFFLLGTL PQNYPQVMKT DSPTFNRFFH 400
    AMLDSGVYYA PALYEAGFVS AAHTAEDIEA TVEAATRFFA GR 442
    Length:442
    Mass (Da):47,088
    Last modified:February 6, 2007 - v1
    Checksum:i4B559C85BDB16F36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38654.1.
    RefSeqiWP_011802725.1. NC_008781.1.
    YP_983575.1. NC_008781.1.

    Genome annotation databases

    EnsemblBacteriaiABM38654; ABM38654; Pnap_3357.
    GeneIDi4689643.
    KEGGipna:Pnap_3357.
    PATRICi22951429. VBIPolNap76733_4236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38654.1 .
    RefSeqi WP_011802725.1. NC_008781.1.
    YP_983575.1. NC_008781.1.

    3D structure databases

    ProteinModelPortali A1VSM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_3357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM38654 ; ABM38654 ; Pnap_3357 .
    GeneIDi 4689643.
    KEGGi pna:Pnap_3357.
    PATRICi 22951429. VBIPolNap76733_4236.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi TVIGHAN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci PNAP365044:GJ8X-3405-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2.

    Entry informationi

    Entry nameiGSA_POLNA
    AccessioniPrimary (citable) accession number: A1VSM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3