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A1VRQ1

- MDH_POLNA

UniProt

A1VRQ1 - MDH_POLNA

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei101 – 1011SubstrateUniRule annotation
Binding sitei108 – 1081NADUniRule annotation
Binding sitei115 – 1151NADUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Active sitei190 – 1901Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NADUniRule annotation
Nucleotide bindingi132 – 1343NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3076-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Pnap_3030
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 328327Malate dehydrogenasePRO_0000294398Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi365044.Pnap_3030.

Structurei

3D structure databases

ProteinModelPortaliA1VRQ1.
SMRiA1VRQ1. Positions 3-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFSQECI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1VRQ1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSKKPVRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEVPVEGPQ
60 70 80 90 100
KALKGVMMEL DDCAFPLLVE MTAHSDPMTA FKDADYALLV GSRPRGPGME
110 120 130 140 150
RAELLAVNGA IFTAQGKALN AVASRDVRVL VVGNPANTNA YIAMKSAPDL
160 170 180 190 200
PAKNFTAMLR LDHNRAASQI AAKTGKAVAD IEKLTVWGNH SPTMYADYRF
210 220 230 240 250
ATIGGESVAQ MINDQEWNAN VFLPTVGKRG AAIIEARGSS SAASAANAAI
260 270 280 290 300
DHMRDWALGT NGKWVTMGIP SGGEYGIPAE TMFGFPVTCE NGEYKIVEGL
310 320
EIDAFSQERI NITLAELEGE KAGVAHLL
Length:328
Mass (Da):34,846
Last modified:February 6, 2007 - v1
Checksum:iF554EB82339F1829
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38329.1.
RefSeqiYP_983250.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM38329; ABM38329; Pnap_3030.
GeneIDi4689791.
KEGGipna:Pnap_3030.
PATRICi22950767. VBIPolNap76733_3907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38329.1 .
RefSeqi YP_983250.1. NC_008781.1.

3D structure databases

ProteinModelPortali A1VRQ1.
SMRi A1VRQ1. Positions 3-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_3030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM38329 ; ABM38329 ; Pnap_3030 .
GeneIDi 4689791.
KEGGi pna:Pnap_3030.
PATRICi 22950767. VBIPolNap76733_3907.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi AFSQECI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci PNAP365044:GJ8X-3076-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiMDH_POLNA
AccessioniPrimary (citable) accession number: A1VRQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3