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A1VRQ1

- MDH_POLNA

UniProt

A1VRQ1 - MDH_POLNA

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Protein
Malate dehydrogenase
Gene
mdh, Pnap_3030
Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei101 – 1011Substrate By similarity
Binding sitei108 – 1081NAD By similarity
Binding sitei115 – 1151NAD By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Active sitei190 – 1901Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NAD By similarity
Nucleotide bindingi132 – 1343NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-3076-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Pnap_3030
OrganismiPolaromonas naphthalenivorans (strain CJ2)
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 328327Malate dehydrogenaseUniRule annotation
PRO_0000294398Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi365044.Pnap_3030.

Structurei

3D structure databases

ProteinModelPortaliA1VRQ1.
SMRiA1VRQ1. Positions 3-328.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFSQECI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1VRQ1-1 [UniParc]FASTAAdd to Basket

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MSKKPVRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEVPVEGPQ    50
KALKGVMMEL DDCAFPLLVE MTAHSDPMTA FKDADYALLV GSRPRGPGME 100
RAELLAVNGA IFTAQGKALN AVASRDVRVL VVGNPANTNA YIAMKSAPDL 150
PAKNFTAMLR LDHNRAASQI AAKTGKAVAD IEKLTVWGNH SPTMYADYRF 200
ATIGGESVAQ MINDQEWNAN VFLPTVGKRG AAIIEARGSS SAASAANAAI 250
DHMRDWALGT NGKWVTMGIP SGGEYGIPAE TMFGFPVTCE NGEYKIVEGL 300
EIDAFSQERI NITLAELEGE KAGVAHLL 328
Length:328
Mass (Da):34,846
Last modified:February 6, 2007 - v1
Checksum:iF554EB82339F1829
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38329.1.
RefSeqiWP_011802401.1. NC_008781.1.
YP_983250.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM38329; ABM38329; Pnap_3030.
GeneIDi4689791.
KEGGipna:Pnap_3030.
PATRICi22950767. VBIPolNap76733_3907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000529 Genomic DNA. Translation: ABM38329.1 .
RefSeqi WP_011802401.1. NC_008781.1.
YP_983250.1. NC_008781.1.

3D structure databases

ProteinModelPortali A1VRQ1.
SMRi A1VRQ1. Positions 3-328.
ModBasei Search...

Protein-protein interaction databases

STRINGi 365044.Pnap_3030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM38329 ; ABM38329 ; Pnap_3030 .
GeneIDi 4689791.
KEGGi pna:Pnap_3030.
PATRICi 22950767. VBIPolNap76733_3907.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi AFSQECI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci PNAP365044:GJ8X-3076-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2.

Entry informationi

Entry nameiMDH_POLNA
AccessioniPrimary (citable) accession number: A1VRQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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