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A1VRF7

- TRMB_POLNA

UniProt

A1VRF7 - TRMB_POLNA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751S-adenosyl-L-methionineUniRule annotation
    Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
    Binding sitei127 – 1271S-adenosyl-L-methionineUniRule annotation
    Active sitei150 – 1501By similarity
    Binding sitei150 – 1501S-adenosyl-L-methionineUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-2976-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Pnap_2936
    OrganismiPolaromonas naphthalenivorans (strain CJ2)
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000000644: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246tRNA (guanine-N(7)-)-methyltransferasePRO_0000288196Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi365044.Pnap_2936.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VRF7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni156 – 1616Interaction with RNAUniRule annotation
    Regioni225 – 2284Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiQDNFLCC.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1VRF7-1 [UniParc]FASTAAdd to Basket

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    MIESSSPTPP ALHEGAPADV SHPRNIRSFV RRTGRTTVGQ AKAFADVGPR    50
    FLLAYSGLPM DFSAVYGRDA PTILEIGFGM GEATAHIAGL MPEKNFLCCE 100
    VHTPGVGALL KRIDEQALTN IRILQHDAVE VIDHMLPLGS LDGAHIFFPD 150
    PWHKTKHNKR RLIQAPLIAK LAARLKPGGY LHCATDWQPY AEQILEVLSA 200
    EPLLKNTADA ASDGYAPKPG YRPLTKFENR GIKLGHGVWD VVFTRA 246
    Length:246
    Mass (Da):26,899
    Last modified:February 6, 2007 - v1
    Checksum:i78D01252E4BADB7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38235.1.
    RefSeqiYP_983156.1. NC_008781.1.

    Genome annotation databases

    EnsemblBacteriaiABM38235; ABM38235; Pnap_2936.
    GeneIDi4687612.
    KEGGipna:Pnap_2936.
    PATRICi22950559. VBIPolNap76733_3809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM38235.1 .
    RefSeqi YP_983156.1. NC_008781.1.

    3D structure databases

    ProteinModelPortali A1VRF7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_2936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM38235 ; ABM38235 ; Pnap_2936 .
    GeneIDi 4687612.
    KEGGi pna:Pnap_2936.
    PATRICi 22950559. VBIPolNap76733_3809.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi QDNFLCC.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci PNAP365044:GJ8X-2976-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2.

    Entry informationi

    Entry nameiTRMB_POLNA
    AccessioniPrimary (citable) accession number: A1VRF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3