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Protein

Putative ribosome biogenesis GTPase RsgA

Gene

rsgA

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+Note: Binds 1 zinc ion per subunit.
  • Zn2+UniRule annotationSAAS annotationNote: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi254 – 2541ZincUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Metal bindingi261 – 2611ZincUniRule annotation
Metal bindingi267 – 2671ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1134GTPUniRule annotation
Nucleotide bindingi170 – 1789GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-1487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribosome biogenesis GTPase RsgAUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:rsgAUniRule annotation
Ordered Locus Names:Pnap_1467Imported
OrganismiPolaromonas naphthalenivorans (strain CJ2)Imported
Taxonomic identifieri365044 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000000644 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer. Associates with ribosomes.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi365044.Pnap_1467.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi254 – 26714Knuckle-like cysteine clusterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.UniRule annotation
Contains CP-type G (guanine nucleotide-binding) domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1162.
HOGENOMiHOG000006957.
KOiK06949.
OMAiKYCFPEF.
OrthoDBiEOG69SKDD.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA.
InterProiIPR010914. EngC_GTPase.
IPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VMA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVAGFGRHV LVETESGQRL ICHPRGKKSQ VVVGDRIRWL PSQDEGTIEK
60 70 80 90 100
IEERSNLFYR QDEMRTKSFA ANLDQILILI AAEPEFSESQ LTRALIAAEA
110 120 130 140 150
ERIKPIIALN KSDLAEPFGR AWTKLAPYRA MGYQVLPLAI KPKTAAAPAN
160 170 180 190 200
DGQTAELMAL LHGKKTLVLG PSGAGKSSLT NLLVPQAKVL TAEISQALNS
210 220 230 240 250
GKHTTTSTTL YWVDEARTTA LIDSPGFQEF GLHHIDPMQL ANYMPDFKAH
260 270 280 290 300
AQDCKFYNCT HLHEPGCGVI SEVKSTVSAS SISANRYRLY SELFAELSQT

RY
Length:302
Mass (Da):33,313
Last modified:February 6, 2007 - v1
Checksum:i79B7B89F2939C4D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM36781.1.
RefSeqiYP_981702.1. NC_008781.1.

Genome annotation databases

EnsemblBacteriaiABM36781; ABM36781; Pnap_1467.
KEGGipna:Pnap_1467.
PATRICi22947541. VBIPolNap76733_2320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000529 Genomic DNA. Translation: ABM36781.1.
RefSeqiYP_981702.1. NC_008781.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi365044.Pnap_1467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM36781; ABM36781; Pnap_1467.
KEGGipna:Pnap_1467.
PATRICi22947541. VBIPolNap76733_2320.

Phylogenomic databases

eggNOGiCOG1162.
HOGENOMiHOG000006957.
KOiK06949.
OMAiKYCFPEF.
OrthoDBiEOG69SKDD.

Enzyme and pathway databases

BioCyciPNAP365044:GJ8X-1487-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA.
InterProiIPR010914. EngC_GTPase.
IPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CJ2Imported.

Entry informationi

Entry nameiA1VMA3_POLNA
AccessioniPrimary (citable) accession number: A1VMA3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.