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A1VLZ3

- UPPP_POLNA

UniProt

A1VLZ3 - UPPP_POLNA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-1375-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Pnap_1356
    OrganismiPolaromonas naphthalenivorans (strain CJ2)
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Undecaprenyl-diphosphatasePRO_0000290743Add
    BLAST

    Proteomic databases

    PRIDEiA1VLZ3.

    Interactioni

    Protein-protein interaction databases

    STRINGi365044.Pnap_1356.

    Structurei

    3D structure databases

    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalUniRule annotationAdd
    BLAST
    Transmembranei44 – 6421HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei218 – 23821HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiVIYFRNE.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    A1VLZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIALLIKAA IMGIVEGLTE FLPISSTGHL ILAGALLGFD DDKAKVFDIA    50
    IQTGAIFAVI LVYWQKIRST LIALPNEKQA QQFALNVLVA FVPAVVLGLL 100
    FGKAIKAHLF TPVVVASAFI VGGFIILWAE KRQQRNPATI RIHDVESMST 150
    MDALKVGLVQ CLAMIPGTSR SGSTIIGGML LGLSRKAATD FSFYLAIPTL 200
    IGAGAYSLFK DRALLSMADA PMFGVGLLFS FLSAWLCIRW LLRYIASHDF 250
    VPFAWYRIAF GIVVLATAWS GVVTWAE 277
    Length:277
    Mass (Da):29,982
    Last modified:February 6, 2007 - v1
    Checksum:i196BF835F3DB62AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM36671.1.
    RefSeqiWP_011800762.1. NC_008781.1.
    YP_981592.1. NC_008781.1.

    Genome annotation databases

    EnsemblBacteriaiABM36671; ABM36671; Pnap_1356.
    GeneIDi4686218.
    KEGGipna:Pnap_1356.
    PATRICi22947315. VBIPolNap76733_2208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM36671.1 .
    RefSeqi WP_011800762.1. NC_008781.1.
    YP_981592.1. NC_008781.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_1356.

    Proteomic databases

    PRIDEi A1VLZ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM36671 ; ABM36671 ; Pnap_1356 .
    GeneIDi 4686218.
    KEGGi pna:Pnap_1356.
    PATRICi 22947315. VBIPolNap76733_2208.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi VIYFRNE.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PNAP365044:GJ8X-1375-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2.

    Entry informationi

    Entry nameiUPPP_POLNA
    AccessioniPrimary (citable) accession number: A1VLZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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