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A1VLZ3 (UPPP_POLNA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Pnap_1356
OrganismPolaromonas naphthalenivorans (strain CJ2) [Complete proteome] [HAMAP]
Taxonomic identifier365044 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290743

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1VLZ3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 196BF835F3DB62AD

FASTA27729,982
        10         20         30         40         50         60 
MDIALLIKAA IMGIVEGLTE FLPISSTGHL ILAGALLGFD DDKAKVFDIA IQTGAIFAVI 

        70         80         90        100        110        120 
LVYWQKIRST LIALPNEKQA QQFALNVLVA FVPAVVLGLL FGKAIKAHLF TPVVVASAFI 

       130        140        150        160        170        180 
VGGFIILWAE KRQQRNPATI RIHDVESMST MDALKVGLVQ CLAMIPGTSR SGSTIIGGML 

       190        200        210        220        230        240 
LGLSRKAATD FSFYLAIPTL IGAGAYSLFK DRALLSMADA PMFGVGLLFS FLSAWLCIRW 

       250        260        270 
LLRYIASHDF VPFAWYRIAF GIVVLATAWS GVVTWAE 

« Hide

References

[1]"Complete sequence of chromosome 1 of Polaromonas naphthalenivorans CJ2."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Madsen E.L., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CJ2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000529 Genomic DNA. Translation: ABM36671.1.
RefSeqYP_981592.1. NC_008781.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING365044.Pnap_1356.

Proteomic databases

PRIDEA1VLZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM36671; ABM36671; Pnap_1356.
GeneID4686218.
KEGGpna:Pnap_1356.
PATRIC22947315. VBIPolNap76733_2208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycPNAP365044:GJ8X-1375-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_POLNA
AccessionPrimary (citable) accession number: A1VLZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families