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A1VKP7

- NADK_POLNA

UniProt

A1VKP7 - NADK_POLNA

Protein

NAD kinase

Gene

nadK

Organism
Polaromonas naphthalenivorans (strain CJ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Binding sitei175 – 1751NADUniRule annotation
    Binding sitei177 – 1771NADUniRule annotation
    Binding sitei212 – 2121NAD; via carbonyl oxygenUniRule annotation
    Binding sitei246 – 2461NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 742NADUniRule annotation
    Nucleotide bindingi147 – 1482NADUniRule annotation
    Nucleotide bindingi188 – 1936NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPNAP365044:GJ8X-919-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Pnap_0908
    OrganismiPolaromonas naphthalenivorans (strain CJ2)
    Taxonomic identifieri365044 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000000644: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291NAD kinasePRO_1000005426Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi365044.Pnap_0908.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VKP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiHPSIPGW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VKP7-1 [UniParc]FASTAAdd to Basket

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    MKSQFRHVAL IGKYQAQGSR SALEDIAHFL GAQGCEVALE EDTARNTGLT    50
    QYPTLDAAGI GAQCDLALVV GGDGTMLGIG RLLAQFGVPV VGINQGRLGF 100
    ITDIGFEHYQ NTLAPMLRGE FEEDRRWMMQ AKVVRDGHCV FRATAMNDVV 150
    VNRGATSGMV ELRVEVDGRF VANQRADGLI IASPTGSTAY ALSAGGPMLH 200
    PSIAGWVLVP IAPHTLSNRP IVLSDSGEVV IEIVAGRDAS ASFDQQSLAT 250
    LLHGDRISVR RSEHQMRFLH PKGWSYFDTL RKKLHWNEGV A 291
    Length:291
    Mass (Da):31,520
    Last modified:February 6, 2007 - v1
    Checksum:i435FA2902AD426C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM36225.1.
    RefSeqiYP_981146.1. NC_008781.1.

    Genome annotation databases

    EnsemblBacteriaiABM36225; ABM36225; Pnap_0908.
    GeneIDi4689510.
    KEGGipna:Pnap_0908.
    PATRICi22946353. VBIPolNap76733_1735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000529 Genomic DNA. Translation: ABM36225.1 .
    RefSeqi YP_981146.1. NC_008781.1.

    3D structure databases

    ProteinModelPortali A1VKP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 365044.Pnap_0908.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM36225 ; ABM36225 ; Pnap_0908 .
    GeneIDi 4689510.
    KEGGi pna:Pnap_0908.
    PATRICi 22946353. VBIPolNap76733_1735.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi HPSIPGW.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PNAP365044:GJ8X-919-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CJ2.

    Entry informationi

    Entry nameiNADK_POLNA
    AccessioniPrimary (citable) accession number: A1VKP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3